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TranscriptomicsTranscription profiling of S. cerevisiae response to stress throughout a 15-day wine fermentation
We used genome-wide expression analyses to study the response of Saccharomyces cerevisiae to stress throughout a 15-day wine fermentation. Forty percent of the yeast genome significantly changed expression levels to mediate long-term adaptation to an environment in which ethanol is both a stressor a...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-8536 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37. A functional genomics approach was used to establish a temporal transcriptional profile and identify differentially expressed gene...
ORGANISM(S): Homo sapiens 
2006-08-01 | E-FPMI-4 | biostudies-arrayexpress
TranscriptomicsSpatial organisation of the X inactivation center
We report the application of Chromosome Conformation Capture Carbon-copy (5C) to a 4.5 Mb stretch of the mouse X chromosome encompassing the X inactivation center locus. We uncover a series of discrete 200kb-1Mb topologically associating domains (TADs). These align with several domain-wide epigenomi...
ORGANISM(S): Mus musculus 
2012-04-11 | E-GEOD-35721 | biostudies-arrayexpress
TranscriptomicsExpression data from c-Myc+ Notch1 T-ALL initiating cells
Missense FBXW7 mutations are prevalent in various tumors, including T-cell acute lymphoblastic leukemia (T-ALL). To study the effects of such lesions, we generated animals carrying regulatable Fbxw7 mutant alleles. We show here that these mutations specifically bolster cancer-initiating cell activit...
ORGANISM(S): Mus musculus 
2013-05-10 | E-GEOD-46797 | biostudies-arrayexpress
TranscriptomicsAbundant Quantitative Trait Loci for CpG Methylation and Expression Across Human Brain Tissues
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation, mRNA...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-15745 | biostudies-arrayexpress
TranscriptomicsDerivation and characterization of Dicer and microRNA deficient human cells
We have used genome editing to generate inactivating deletion mutations in all three copies of the dicer (hdcr) gene present in the human cell line 293T. As previously shown in murine ES cells lacking Dicer function, hDcr-deficient 293T cells are severely impaired for the production of mature microR...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-56836 | biostudies-arrayexpress
TranscriptomicsIdentification of novel, highly expressed retroviral microRNAs in cells infected by bovine foamy virus
While numerous viral microRNAs (miRNAs) expressed by DNA viruses, especially herpesvirus family members, have been reported, there have been very few reports of miRNAs derived from RNA viruses. Here we describe three miRNAs expressed by bovine foamy virus (BFV), a member of the spumavirus subfamily ...
ORGANISM(S): Bos taurus 
2015-04-07 | E-GEOD-67620 | biostudies-arrayexpress
UnknownGenetic variants for head size share genes and pathways with cancer.
Not available
S-EPMC11148644 | biostudies-literature
UnknownGenome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
Not available
S-EPMC11245051 | biostudies-literature
UnknownVariation in wood density across South American tropical forests.
Not available
S-EPMC11893774 | biostudies-literature
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