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MetabolomicsACOD1 deficiency promotes dermal papilla cell senescence via mitochondrial dysfunction in androgenetic alopecia

Background Androgenetic alopecia (AGA), the most prevalent form of hair loss, is driven by the dysfunction of dermal papilla cells (DPCs). Emerging evidence implicates DPC senescence in the pathogenesis of AGA; however, the underlying molecular mechanisms remain incompletely elucidated.

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2026-05-23 | MTBLS14024 | MetaboLights
TranscriptomicsComparative gene expression analysis of 2 subpopulations of dermal papilla cells.
Different types of hair follicles can be found in the skin of mice. It is believed that the signals that control hair follicle differentiation arise from cells in a structure called the dermal papilla. Understanding the nature of those signals is of interest for the biology of the normal tissue. We...
ORGANISM(S): Mus musculus 
2009-06-26 | E-GEOD-16801 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epithelial stem cells co-cultured with the dermal papilla
Clonogenic keratinocyte stem cells isolated from the bulge area of human telogen follicles were co-cultured with dermal papilla cells in a transwell system. RNA was isolated from stem cells for different periods of time (day 0, 1, 2, and 5) after co-culture with DP and analyzed for changes in gene e...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1470 | biostudies-arrayexpress
ProteomicsHuman,scalp,dermal papilla cells,LC-MS/MS
Three individual patient-originated (Scalp trauma; ages 37, 46 and 57) DPCs were used for the studies. Dermal papilla cells, derived from the frontal scalp of 3 women, were treated with normal medium (Ctrl group) and medium containing 10-7 M corticotropin-releasing hormone (CRH group) for 72 h. Prot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057745 | Pride
Human Lc-ms/ms Scalp Dermal papilla cells 
TranscriptomicsGlobal profiling of human hair follicle scalp dermal papilla cells using Affymetrix microarrays
Dermal papilla cells isolated from the human hair follicle are capable of inducing hair growth in recipient epithelia. However, demonstrating disparity from rodent dermal papilla, human cells lose this inductive competance immediately upon growth in culture under normal growth conditions. We grew ...
ORGANISM(S): Homo sapiens 
2013-10-20 | E-GEOD-44765 | biostudies-arrayexpress
ProteomicsHuman dermal papilla cell culture medium iTRAQ
Alopecia is an exceedingly prevalent problem and lacks effective therapy. Recently, research has focused on early-passage dermal papilla cells (DPCs), which have hair inducing activity both in vivo and in vitro. Our previous study indicated that factors secreted from early-passage DPCs contribute to...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004201 | Pride
Human Dermal papilla cell Itraq 
TranscriptomicsAMPK activation exerts anti-senescence effect in human follicle dermal papilla cells
We investigated the role of AMPK activation in the progression of senescence in HFDPCs. The anti-senescence effects of adenine, a recently identified AMPK activator, were determined in a comparison with AICAR, a pharmacological AMPK activator, in HFDPCs. The results showed that either adenine or AIC...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-62798 | biostudies-arrayexpress
GenomicsHomo sapiens strain:Hair Follicle Dermal Papilla Cells (HFDPC)
Transcriptional changes of human follicle dermal papilla cells upon porphyra-334 treatment
PRJNA663440 | ENA
GenomicsExpression data from human dermal papilla cells
Expression data from human dermal papilla cells
PRJNA1246141 | ENA
GenomicsHomo sapiens strain:dermal papilla cell
Transcriptome analysis of human dermal papilla cells with wild type, K4DT, SV40, E6E7
PRJDB9860 | ENA
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