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Proteomic analysis of hair follicles aids in basic understanding of human scalp hair biology, and it can serve as a foundation for biomarker identification and targeted therapy in precision medicine. Proteomics of scalp hair follicles in Indian population has not been reported earlier. We have perfo...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD034166 | Pride
Scalp microbiome
Three individual patient-originated (Scalp trauma; ages 37, 46 and 57) DPCs were used for the studies. Dermal papilla cells, derived from the frontal scalp of 3 women, were treated with normal medium (Ctrl group) and medium containing 10-7 M corticotropin-releasing hormone (CRH group) for 72 h. Prot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057745 | Pride
EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of hair follicle immune privilege and differential modulation of IL-33 and IL-37 expression. Our findings suggest that successful future management of EGFRi/MEKi-induced folliculitis requires r...
ORGANISM(S): Homo sapiens 
Adipose transcriptome in the scalp of androgenetic alopecia
Lichen planopilaris (LPP) is a chronic inflammatory disease of unknown pathogenesis that leads to permanent hair loss. Whilst destruction of epithelial hair follicle stem cells (eHFSCs) that reside in an immunologically protected niche of the HF epithelium, the bulge, is a likely key event in LPP pa...
ORGANISM(S): Homo sapiens 
To identify differentially expressed genes in androgenetic alopecia specifically in the adipose, adipose tissue samples from affected male participants were collected through punch biopsy at two different sites: bald (frontal) and normal (occipital,as control) scalp. After removal of the epidermis, ...
ORGANISM(S): Homo sapiens 
2023-08-30 | GSE212757 | GEO
Gene expression analysis in human scalp biopsies from lichen planopilaris patients
CD133 is expressed by a subpopulation of human fetal hair follicle placode cells during early hair development. Its expression, which is gradually lost as the placode matures, correlates with early morphogenesis. We used microarrays to analyze differences in gene expression between alpha-6 integrin+...
ORGANISM(S): Homo sapiens 
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