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ProteomicsPP2A Phosphatase Regulatory Subunit PPP2R3C is a New Positive Regulator of the Hedgehog Signaling Pathway
Cellular signaling pathways rely on posttranslational modifications (PTMs) to finely regulate protein functions, particularly transcription factors. The Hedgehog (Hh) signaling cascade, crucial for embryonic development and tissue homeostasis, is susceptible to aberrations that lead to developmental...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-10 | PXD054802 | Pride
Ppp2r3c  pp2a  phosphatases  hedgehog signaling  gli  phosphorylation  
ProteomicsTIPRL1 and its ATM-dependent phosphorylation modulate the DNA Damage Response to promote radiotherapy resistance in head and neck cancer
TIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6 – all pleiotropic modulators of the DNA Damage Response (DDR). Here, we describe a new role for TIPRL1 in the radiotherapy (RT) response of Head and Neck Squa...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD044931 | Pride
Ataxia telangiectasia mutated (atm) kinase/ dna damage response (ddr)/ head and neck squamous cell carcinoma (hnscc)/ radioresistance/ target of rapamycin signaling pathway regulator-like 1 (tiprl1) 
ProteomicsStructural mechanism for inhibition of PP2A-B56 and oncogenicity by CIP2A
Abstract The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56 is a human tumor suppressor. However, the molecular mechanisms inhibiting PP2A-B56in cancer are poorly understood. Here, we report molecular level details and structural mechanism of PP2A-B56inhibition by an oncoprotein CIP2A. Upon di...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD030297 | Pride
Ap-ms Protein phosphatase Mouse Oncogene Interactome 
ProteomicsDisturbed Balance of Protein Phosphatase Type 2A (PP2A) is Driving Epithelial-to-Mesenchymal Transition in Human Pan-creatic Cancer Patients
The incidence for pancreatic ductal adenocarcinoma (PDAC) is rising which has a low survival rate. In cancer, Epithelial-to-Mesenchymal transition (EMT) contribute to an aggressive phenotype. Protein Phosphatase Type 2A (PP2A) are initially regarded as tumor suppressors, the connection with EMT in p...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037976 | Pride
Pancreatic cancer  epithelial-to-mesenchymal progression  protein phosphatases type 2a  gene expression  proteomics  in vivo results  drug target 
ProteomicsExtracellular vesicle-derived miRNAs improve stem cell-based therapeutic approaches in muscle wasting conditions.
Skeletal muscle holds an intrinsic capability of growth and regeneration both in physiological conditions and in case of injury. Chronic muscle illnesses, generally caused by genetic and acquired factors, lead to deconditioning of the skeletal muscle structure and function, and are associated with a...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-09 | PXD035446 | Pride
Aging Mirna Muscular dystrophy Skeletal muscle Hypertrophy Extracellular vesicle 
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