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TranscriptomicsComparison of coding RNA expression in steady-state and in response to IL33 and IL5 stimulation in bone marrow eosinophils from IL5-deficient and wild-type littermates
Aim of the experiment was to assess differences in expression of coding RNA between bone marrow eosinophils arising in IL-5 knock-out mice (C57BL/6-Il5tm1Kopf/J) or wild-type littermates and their response to cytokine stimulation. Bone marrow eosinophils were sorted by FACS submitted to RNA-seq imme...
ORGANISM(S): Mus musculus 
2021-12-17 | E-MTAB-10188 | biostudies-arrayexpress
ProteomicsControl vs Elp3-deficient mouse myeloid progenitors 6-plex TMT LC-MSMS
6-plex TMT LC-MSMS quantification of proteins in myeloid progenitors (Lineage- Sca1- Kit+ cells) isolated from the bone marrow of 8-12 week old male and female control and Elp3-deficient (Elp3fl/fl vav-iCreT/+) mice. Biological triplicates of each genotype were analyzed, each consisting of 1.10e6 ce...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-26 | PXD010486 | Pride
Elongator Myeloid progenitor Elp3 Trna Hematopoiesis 
TranscriptomicsComparison of coding RNA expression of blood eosinophils from mepolizumab- or omalizumab-treated severe asthmatic patients and from healthy controls
RNA-seq comparison of coding RNA expression in blood eosinophils from patients with severe allergic eosinophilic asthma treated with mepolizumab with those of healthy controls and matched severe asthmatic patients receiving omalizumab.
ORGANISM(S): Homo sapiens 
2021-12-17 | E-MTAB-10190 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to ex vivo IL33 stimulation of blood eosinophils from mepolizumab- or omalizumab-treated patients
Coding RNA expression of blood eosinophils from mepolizumab- or omalizumab-treated patients stimulated ex vivo with IL-33 for 6 hours and of directly processed non-stimulated blood eosinophils from the same samples (paired design)
ORGANISM(S): Homo sapiens 
2021-12-17 | E-MTAB-10189 | biostudies-arrayexpress
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