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ProteomicsArchitecture of the yeast Elongator complex
The highly conserved eukaryotic Elongator complex performs specific chemical modifications on wobble base uridines of tRNAs, which are essential for proteome stability and homeostasis. The complex is formed by six individual subunits (Elp1-6) that are all equally important for its tRNA modification ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-12-20 | PXD005251 | Pride
Trna modification Elongator Yeast Electron microscopy Saccharomyces cerevisiae 
ProteomicsElongator complex deficiency in sonic hedgehog medulloblastoma
Cancer genomics has illuminated a wide spectrum of genes and core molecular processes contributing to human malignancy. Still, the genetic and molecular basis of many cancers remains only partially explained. Genetic predisposition accounts for 5-10% of cancer diagnoses and genetic events cooperatin...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD016832 | Pride
Elongator complex Meduloblastoma Elp1 Shh 
ProteomicsCryo-EM structures of the human Elongator complex at work
The deposited data concern the mapping of acetylation sites on wild-type and the K280A, Y363A mutants of Elp3 by LC-MS/MS. Abstract of the manuscript: tRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092998 | MassIVE
ProteomicsDrosophila S2s Elongator identification
A collection of stable Drosophila S2 cell lines was established, each one expressing a (His)-PC SNAP tagged version of each of the six Elongator subunits. From these stable lines, the endogenous Elongator complex can be recovered by pulling on the exogenous subunit via the PC tag. This allowed us to...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-09-15 | PXD036556 | Pride
Elongator Drosophila S2 
GenomicsiyCosElon
Cosmoconus elongator, iyCosElon
PRJEB125621 | ENA
TranscriptomicsPlant Elongator in light signaling
Elongator is a histone acetyltransferase (HAT) complex associated with RNA polymerase II (RNAPII) to facilitate transcription elongation. It consists of subunits Elp1-6, with Elp3 conferring HAT activity. Elongator is conserved in yeast, plants and humans. In humans, mutations in Elp genes cause neu...
ORGANISM(S): Arabidopsis thaliana 
2018-01-23 | GSE42053 | GEO
GenomicsiyCosElon
Cosmoconus elongator, genomic and transcriptomic data
PRJEB125620 | ENA
ProteomicsElongator is a microtubule polymerase selective for poly-glutamylated tubulin: ELP456 to Tubulin crosslinking
Elongator is a tRNA-modifying complex regulating protein translation. Recently, a moonlighting function of Elongator has been identified in regulating the polarization of the microtubule cytoskeleton during asymmetric cell division. Elongator induces symmetry breaking of the anaphase midzone by sele...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-05-07 | PXD058480 | Pride
Tubulin crosslinking elp456 
ProteomicsElongator is required for pattern recognition receptor and type I interferon signaling in macrophages.
Innate immune detection of pathogens by macrophages requires a rapid and large scale mobilisation of cellular resources towards an appropriate immune response, mainly involving altered protein expression. Pathogen recognition is mediated by pattern recognition receptor (PRR) sensing of conserved mic...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD064630 | Pride
Innate immunity  interferon  interferon regulatory factor (irf)  lipopolysaccharide (lps)  macrophage  pattern recognition receptor (prr)  stat transcription factor  toll-like receptor 4 (tlr4)  virus  elongator 
GenomicsGermline elongator mutations in sonic hedgehog medulloblastoma
Cancer genomics has illuminated a wide spectrum of genes and core molecular processes contributing to human malignancy. Still, the genetic and molecular basis of many cancers remains only partially explained. Genetic predisposition accounts for 5-10% of cancer diagnoses and genetic events cooperatin...
EGAS00001004126 | EGA
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