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TranscriptomicsTranscription profiling of human invasive and non-invasive non-functioning pituitary adenomas
Context : Non Functioning Pituitary Adenomas (NFPAs), although typically benign, may be locally invasive. Few datas are currently available related to the molecular process of invasion in sporadic pituitary adenomas. Markers of invasiveness, important for helping the clinician in the therapeutic s...
ORGANISM(S): Homo sapiens 
2010-03-18 | E-TABM-899 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human malignant or benign breast cancer tumors to identify genes that present a differential expression between the two types of lesion
Background. Although gene expression arrays have been used to generate molecular predictors of relapse and drug sensitivity in breast cancer, no large study describes genes and exons differentially expressed between breast cancer and benign lesions.

Methods. One hundred and sixty-five tumour...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-TABM-609 | biostudies-arrayexpress
TranscriptomicsExpression and CGHarray profiling of Hepatosplenic T-cell Lymphomas (10 tumor samples)
A Cartes dIdentite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 10 HSTL samples including biopsies (n=6), sorted tumor cells (n=3), cell line (n=1) | Agilent SurePrint G3 Human CGH Microarray 4x180K Arrays ...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-MTAB-638 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of human de novo actue myeloid leukemia (p-AML) samples and normal samples
Therapy-related acute myeloid leukemia (t-AML) is a severe complication of the cytotoxic therapy used for primary cancer treatment. The outcome of these patients is poor compared to people who develop de novo acute myeloid leukemia (p-AML). Chromosome abnormalities in t-AML are partly dependent on t...
ORGANISM(S): Homo sapiens 
2011-05-18 | E-TABM-1014 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of a mother and daughter with a familial translocation t(2;6)(p25;p21) balanced in the mother and unbalanced in the daughter to determine breakpoint location and contribute to a map of haplotolerant genes
A 244 K genome-wide array based comparative genomic hybridization study was carried out in a familial translocation t(2;6)(p25;p21) balanced in the mother (SDM) and unbalanced in her daughter (SD). In the past, this translocation has allowed to localize the HLA multigene cluster to chromosome 6. Wit...
ORGANISM(S): Homo sapiens 
2008-12-31 | E-TABM-308 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVECs) transduced with pMLV-MCS or pMLV-THAP1 retroviral expression vectors
Goal of the experiment : Retroviral-mediated gene transfer of the THAP-zinc finger protein THAP1 inhibits endothelial cell proliferation through coordinated repression of critical cell cycle regulators and pRB-E2F target genes. Experimental design: To gain insight into the effects of THAP1 on endo...
ORGANISM(S): Homo sapiens 
2006-09-11 | E-TABM-24 | biostudies-arrayexpress
TranscriptomicsIGR_MITF_STUDY_BBRB
A recent study of the characteristics of coexisting melanoma and renal cell carcinoma RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia associated transcription factor (MITF) was proposed to act as a melanoma oncogene;...
ORGANISM(S): Homo sapiens 
2011-09-03 | E-TABM-1198 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 23 human nevi with a pool of primary cutaneous melanoma
Genomic profiles comparing 23 nevi with a pool of primary cutaneous melanoma
ORGANISM(S): Homo sapiens 
2009-04-16 | E-TABM-3 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of MKL1 in human megakaryocytes derived from cord blood or cytapheresis
Characterize the genes regulated by MKL1/SRF complex in human megakaryocytes (MKs) derived from cord blood or cytapheresis : Using a knock down approach by small interference of MKL1 in MK progenitors, we observed a decrease in the percentage of cells with actin polymerization after adhesion on vari...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-TABM-640 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cohort of human cutaneous primary melanomas associated with a distant metastasis free survival
Identification of genomic characteristics in a cohorte of human cutaneous primary melanoma associated with a distant metastasis free survival.
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-1 | biostudies-arrayexpress
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