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Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by overexpressing OCT4, SOX2, KLF4 and MYC. Although this cell fate transition is a slow and inefficient process, inhibiting several epigenetic barriers has shown to facilitate it. A previously employed epigenetic focused CR...
ORGANISM(S): Homo sapiens 
2023-07-31 | GSE225151 | GEO
Histone modifications perform a vast array of functions in regulating gene expression, DNA replication, and repair. Monoubiquitination of histone H2B at K123 in yeast (K120 in humans) is an intriguing modification because it is deposited cotranscriptionally, mediates the installation of several othe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-16 | PXD051971 | Pride
Limited proteolysis combined with mass spectrometry of farrerol treated. Briefly, cell lysates containing approximately 500 μg of total protein sample were incubated with farrerol or vehicle (DMSO) for 10 min at 25 °C. Proteinase K (5 μg, Sigma–Aldrich) was added simultaneously to each sample for t...
ORGANISM(S): Homo Sapiens 
2022-08-25 | PXD036308 |
Investigating the role of USP22 in reprogramming
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