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MetabolomicsPenicillium-Mediated Toxicity and Microbial Dysbiosis Are Associated with Fruiting Body Abortion in Artificially Cultivated Ophiocordyceps sinensis

The Chinese caterpillar fungus, Ophiocordyceps sinensis, is a valuable medicinal entomopathogenic fungus, but artificial cultivation is hindered by fruiting body abortion, severely impacting yield and quality. The interactions between the fungus, its host insects, and soil are critical for its de...

2026-06-24 | MTBLS14844 | MetaboLights
MetabolomicsMulti-omics profiling identifies MAPK signaling suppression associated with tetracycline-induced root toxicity in soybean
Tetracycline (TC), a widely used veterinary antibiotic, is a pervasive emerging contaminant threatening crop production. Here, we employed integrated physiological, metabolomic, and transcriptomic analyses to decipher the response of soybean (Glycine max L.) to TC. While seed germination was unaffec...
2026-09-07 | MTBLS15077 | MetaboLights
ProteomicsLarge scale toxicoepigenetics on histones: a mass spectrometry-based screening assay applied to developmental toxicity
Toxicoepigenetics is an emerging field that studies the toxicological impact of compounds on protein expression through heritable, non-genetic mechanisms, such as histone post-translational modifications (hPTMs). Due to substantial progress in the large-scale study of hPTMs, integration into the fie...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-17 | PXD026468 | Pride
Histone post-translational modifications Drug screening Toxicoepigenetics Developmental toxicity Lc-ms/ms 
GenomicsSystems modeling of developmental vascular toxicity
Systems modeling of developmental vascular toxicity
PRJNA547772 | ENA
TranscriptomicsAnalysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by microcystin arginine arginine (MC-RR).
In this study, we used zebrafish embryos as a model system to investigate the toxic effects of MC-RR on early development and try to elucidate the underlying developmental toxicological mechanisms in a global view at posttranscriptional level. Altered expression pattern of miRNAs in embryos treated ...
ORGANISM(S): Danio rerio 
2012-09-17 | E-GEOD-29329 | biostudies-arrayexpress
TranscriptomicsDevelopment of a Neural Teratogenicity Test Based on Human Embryonic Stem Cells- Response to Retinoic Acid Exposure
The aim of this study was the development of an alternative testing method based on human embryonic stem cells for prenatal developmental toxicity with particular emphasis on early neural development. To this purpose, we designed an in vitro protocol based on the generation of neural rosettes, repre...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-MEXP-3577 | biostudies-arrayexpress
GenomicsStructure-Dependent Developmental Toxicity of Alkyl-Substituted Naphthalenes
Structure-Dependent Developmental Toxicity of Alkyl-Substituted Naphthalenes
PRJNA1259243 | ENA
TranscriptomicsKidney toxicity in miR-155-/- mice
The development of nephrotoxicity limits the maximum achievable dosage and treatment intervals for cisplatin chemotherapy. Therefore, identifying mechanisms that regulate this toxicity could offer novel methods to optimize cisplatin delivery. MicroRNAs are capable of regulating many different genes,...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-57292 | biostudies-arrayexpress
GenomicsPhotoperiod perturbations impact PFNA induced developmental toxicity [PFNA-5day]
Photoperiod perturbations impact PFNA induced developmental toxicity [PFNA-5day]
PRJNA1365898 | ENA
GenomicsLurasidone Induces Developmental Toxicity and Behavioral Impairments in Zebrafish Embryos
Lurasidone Induces Developmental Toxicity and Behavioral Impairments in Zebrafish Embryos
PRJNA1277809 | ENA
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