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TranscriptomicsDifferences in gene expression patterns in mouse embryonic fibroblast Flp-In-3T3 cell lines stably expressing Pax6 or Pax6(5a).
Novel target genes for the two transcription factor isoforms Pax6 and Pax6(5a) were identified by generating mouse embryonic fibroblast cell lines stably expressing either Pax6 or Pax6(5a), and comparing their gene expression pattern with the original mouse embryonic fibroblast cell line. Flp-In-3T3...
ORGANISM(S): Mus musculus 
2012-03-22 | E-GEOD-31402 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 cells
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on the proliferation and survival of these cells. We used microarray to understand the contribution of FGFR sig...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19220 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 cells and 4T1 tumors
This SuperSeries is composed of the following subset Series: GSE19220: Expression data from TKI258 treated 4T1 cells GSE19221: Expression data from TKI258 treated 4T1 tumors Refer to individual Series
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19222 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 tumors
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on 4T1 tumors in-vivo. We used microarray to understand the contribution of FGFR signaling to the tumor formati...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19221 | biostudies-arrayexpress
TranscriptomicsPax6 mutant neocortex vs. wild type
Pax6 is a transcription factor with key functional roles in embryonic development. In order to identify downstream effectors of Pax6 in the developing cerebral cortex we performed microarray analysis. We compared gene expression profiles of cortical tissues isolated from wild type and Pax6-/- mouse ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32271 | biostudies-arrayexpress
TranscriptomicsAsymmetric cancer cell division regulated by AKT, Reactive Oxygen Species (ROS) high versus ROS low mRNA
Human tumors often contain slowly proliferating cancer cells that resist treatment but we do not know precisely how these cells arise. We show that rapidly proliferating cancer cells can divide asymmetrically to produce slowly proliferating “G0-like” progeny that are enriched following chemotherapy ...
ORGANISM(S): Homo sapiens 
2011-07-14 | E-GEOD-30465 | biostudies-arrayexpress
GenomicsIdentification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during lens and forebrain development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation and cell fate specification...
ORGANISM(S): Mus musculus 
2015-07-09 | E-GEOD-66961 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human neuroectoderm or embryonic stem cells after Pax6 knockdown
Stable Pax6 and Luciferase knockdown human embryonic stem cell lines (H9) were made through lentiviral infection. Two different Pax6 RNAi lines and two Luciferase RNAi lines were then differentiated to neuroectoderm cells for 6 days. mRNA pooled from these two individual lines were then subjected to...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-MEXP-2668 | biostudies-arrayexpress
TranscriptomicsHT-SELEX of recombinant C2H2 zinc finger domains of Sall4
To define the sequence preference of SALL4 C2H2 zinc finger domains, we performed SELEX coupled with high-throughput sequencing (HT-SELEX) using the purified SALL4 ZFC1, ZFC2 and ZFC4 domains combined with no protein control experiment.
ORGANISM(S): artificial sequences 
2021-01-05 | E-MTAB-9236 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dormant and activated blastocysts
Delayed implantation occurs in many mammals, but the underlying mechanisms that direct this process remain largely unknown. In mice, ovariectomy prior to the preimplantation ovarian estrogen secretion on day 4 of pregnancy initiates blastocyst dormancy, which can be maintained for more than 200 days...
ORGANISM(S): Mus musculus 
2004-07-09 | E-MEXP-132 | biostudies-arrayexpress
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