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TranscriptomicsDGCR8 is required for microRNA maturation
To determine whether DGCR8 is required for maturation of all miRNAs, we performed miRNA microarray analysis. Using RNA from wild-type ES cells as our reference sample, we observed a global loss of miRNAs in DGCR8 knockout cells, but normal levels of expression in DGCR8 heterozygous cells. The simil...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-6586 | biostudies-arrayexpress
TranscriptomicsDGCR8 HITS-CLIP reveals novel functions for the Microprocessor (CLIP-seq)
The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 contains two double-stranded RNA binding motifs that recognize the RNA substrate, whereas Drosha functions as the endonuclease. We have used high-throughput sequencing of RNAs isolated by crosslinking immuno...
ORGANISM(S): Homo sapiens 
2012-07-15 | E-GEOD-39086 | biostudies-arrayexpress
ProteomicsStabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis
DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex for microRNA biogenesis. However, the non-canonical functions of DGCR8 have not been studied. Here, we demonstrate that DGCR8 plays an important role in maintaining heterochromatin organizatio...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD013856 | Pride
Dgcr8 Heterochromatin Aging 
TranscriptomicsRegulation of the microRNA processor DGCR8 by the tumor suppressor ING1
The ING familiy of tumor suppressor proteins control several cellular functions relevant to anti-tumor protection, like cell-cycle control, apoptosis, senescence or migration. ING proteins are functionally linked to the p53 pathway, and they participate in transcriptional control via the recognisit...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18645 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of miRNAs regulated by Ars2 and DGCR8
siRNAs were used to deplete either Ars2 or DGCR8 proteins from cells and were compared to control siRNA treated cells.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MTAB-898 | biostudies-arrayexpress
TranscriptomicsExpression data of wild type and C-DGCR8 KO cones at different timepoints [array]
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion. Cones were isolated by FACS from wil...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58493 | biostudies-arrayexpress
TranscriptomicsExpression data of wild type and C-DGCR8 KO cones at different timepoints [RNA-seq]
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion. Cones were isolated by FACS from wil...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58498 | biostudies-arrayexpress
TranscriptomicsMutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors
Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find novel therapeutic leads for this subgroup of patients, we analyzed 58 blastemal-type Wilms tumors by exome and transcriptome sequ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60081 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mRNAs regulated by Ars2 and DGCR8
siRNAs were used to deplete either Ars2 or DGCR8 proteins from cells and were compared to control siRNA treated cells.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MTAB-899 | biostudies-arrayexpress
TranscriptomicsExpression profiling of miR-294 and Mbd2 siRNA transfected Dgcr8-/- mESCs by high throughput sequencing
RNA-seq analysis on CTR, miR-294, and siMbd2 transfected Dgcr8-/- ESCs showed that Mbd2 is responsible for the change of expression of a significant portion of genes that are regulated by miR-290 cluster mRNA profiles of CTR, miR-294 and siMbd2 transfected Dgcr8-/- ESCs were generated by deep sequen...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-64428 | biostudies-arrayexpress
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