Sort   by:  
 Page size 
MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
TranscriptomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Some T's in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (?-D-glucosyl-hydroxymethyluracil). In Leishmania about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA Polymerase II ter...
ORGANISM(S): Leishmania major 
2011-10-15 | E-GEOD-32976 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression data from A/J mouse and A/J-12SM consomic mouse
SMXA-5 mouse shows a high-fat induced fatty liver. The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. The liver triglycerides content of A/J-12SM consomic mouse, a chromosome substitution strain, was suppressed compared to that of A/J mouse. We compared the hepatic gene...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-67340 | biostudies-arrayexpress
GenomicsHuman Hg J resequencing
A finely resolved phylogeny of Y chromosome Hg J illuminates the processes of Phoenician and Greek colonizations in the Mediterranean
PRJEB25861 | ENA
TranscriptomicsGenetic Loci that Regulate Ectopic Calcification in Response to Knee Trauma in LG/J by SM/J Advanced Intercross Mice
Ectopic calcification in synovial tissues is devastating to diarthrodial joints. While some forms of synovial ectopic calcification have genetically simple basis, most cases manifest as complex traits with environmental and multigenic components. The location of causal loci or the physiological proc...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64793 | biostudies-arrayexpress
TranscriptomicsA Highly Sensitive and Unbiased Approach for Elucidating Antibody Repertoires
Developing B lymphocytes undergo V(D)J recombination to assemble germline V, D, and J gene segments into exons that encode the antigen-binding variable region of immunoglobulin (Ig) heavy (H) and light (L) chains. IgH and IgL chains associate to form the B cell receptor (BCR), which upon antigen bi...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82126 | biostudies-arrayexpress
TranscriptomicsMechanisms of CS-related A/J lung tumorigenesis
The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening system in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops tumors spontaneously. Moreover, there is a considerable...
ORGANISM(S): Mus musculus 
2014-08-29 | E-MTAB-1872 | biostudies-arrayexpress
TranscriptomicsMechanisms of CS-related A/J lung tumorigenesis
The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening system in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops tumors spontaneously. Moreover, there is a considerable...
ORGANISM(S): Mus musculus 
2014-08-29 | E-MTAB-1871 | biostudies-arrayexpress
ProteomicsDeuterium-free, Three-plexed Peptide Di-Ethylation for Highly Accurate Quantitative Proteomics
The deuterium, frequently used stable isotope in isotopic labeling for quantitative proteomics, could deteriorate the accuracy and precision of proteome quantification owing to the retention time shift of deuterated peptides from the hydrogenated counterpart. Herein, we introduce a novel three-plexe...
ORGANISM(S): Homo sapiens (Human) 
2019-01-17 | PXD012117 | Pride
Isobaric labeling Quantitative accuracy Di-methylation Isotopic labeling Deuterium effect Di-ethylation 
TranscriptomicsExpression data from follicle associated epithelium (FAE) of small intestine in wild type C57BL/6 mice or mice depleted with RBP-J (by VillinCre-Rbpjflox/flox)
To investigate the role of RBP-J in regulating epithelial cell differention in small intestine, we isolated FAE from mice depleted with RBP-J FAE were isolated from mice described above. Total RNA were extracted from the tissue by QIAGEN Rneasy mini kit.
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-61058 | biostudies-arrayexpress
Sort   by:  
 Page size