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TranscriptomicsChromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue.
The mucosae of the oral cavity are different at the histological level but are all exposed to common genotoxic agents. As a result of this exposure, changes in the mucosal epithelia develop giving rise to Oral Potentially Malignant Lesions (OPMLs), which with time may in turn progress to Oral Squamo...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-28868 | biostudies-arrayexpress
TranscriptomicsGenomic aberrations in distant fields from oral potentially malignant lesions by high resolution DNA flow cytometry and array-CGH
The aim of the study was to address the concept of field cancerization in oral cancer. The presence of genomic aberrations, indicative of chromosomal instability (CIN), in oral distant fields (ODFs) of visually normal and non-dysplastic mucosa at the mirror image from concomitant oral potentially ma...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28906 | biostudies-arrayexpress
ProteomicsThe Carnosine–HNE Michael Adduct as a Redox-Active Species Associated with Nrf2-Dependent Antioxidant and An-ti-Inflammatory Responses
Carnosine (CAR), an endogenous histidine-containing dipeptide, exhibits antioxidant and anti-inflammatory activity in various experimental models; however, its molecular mechanism of action remains poorly understood. Here, we demonstrate that the Michael adduct between CAR and 4-hydroxy-2-nonenal (H...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD075159 | Pride
Carnosine  4-hydroxy-2-nonenal (hne)  nrf2 activation  nf-κb  anti-inflammatory  anti-oxidant. 
ProteomicsEXPLORING THE ANTI-INFLAMMATORY POTENTIAL OF THINNED APPLE POLYPHENOLS: MECHANISTIC PROTEOMICS INSIGHTS INTO DNBS-INDUCED COLITIS MODEL IN MICE
Ulcerative colitis (UC) is a multifactorial inflammatory bowel disease (IBD) with increasing incidence worldwide. Current treatments, such as NSAIDs and corticosteroids, provide partial symptom relief but are associated to significant side effects. This highlights the need for novel therapies with f...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD056914 | Pride
Nf-κb  nrf2  anti-inflammatory  anti-oxidant  polyphenols  proteomics  thinned apples 
UnknownAn intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress
Not available
S-SCDT-10_1038-S44321-024-00132-Z | biostudies-other
UnknownBNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?
Not available
S-EPMC9081904 | biostudies-literature
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
UnknownA 'Multiomic' Approach of Saliva Metabolomics, Microbiota, and Serum Biomarkers to Assess the Need of Hospitalization in Coronavirus Disease 2019.
Not available
S-EPMC8818445 | biostudies-literature
TranscriptomicsCalcineurin/NFAT signaling inhibits myeloid hematopoiesis in mice.
Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signaling can also mediate granulocyte and DC activation, but it is unknown whether NFAT influences their development from progenitors. Here w...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-29094 | biostudies-arrayexpress
UnknownThe impact of vaccination status on post-acute sequelae in hospitalized COVID-19 survivors using a multi-disciplinary approach: An observational single center study.
Not available
S-EPMC11617281 | biostudies-literature
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