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ModelsCollombet2016 - Lymphoid and myeloid cell specification and transdifferentiation
Collombet2016 - Lymphoid and myeloid cell specification and transdifferentiation This model is described in the article: Logical modeling of lymphoid and myeloid cell specification and transdifferentiation Samuel Collombet, Chris van Oevelen, Jose Luis Sardina Ortega, Wassim Abo...
2017-06-08 | MODEL1610240000 | BioModels
GenomicsC/EBPα poises B cells for rapid reprogramming into iPS cells [ChIP-Seq]
C/EBPα induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBPα accomplishes these effects is unclear. We now found that transient C...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52373 | biostudies-arrayexpress
TranscriptomicsC/EBP? poises B cells for rapid reprogramming into iPS cells [RNA-Seq]
C/EBP? induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBP? accomplishes these effects is unclear. We now found that transient C...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52396 | biostudies-arrayexpress
GenomicsC/EBPM-NM-1 poises B cells for rapid reprogramming into iPS cells
C/EBPM-NM-1 induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBPM-NM-1 accomplishes these effects is unclear. We now found that t...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52397 | biostudies-arrayexpress
TranscriptomicsOvercoming the stochastic phase of iPS cells reprogramming by a pulse of C/EBPα [array]
Somatic cell reprogramming into pluripotent stem cells induced by Oct4, Sox2, Klf4 and Myc (OSKM) occurs at low frequencies and with a considerable delay involving a stochastic phase. In contrast, transdifferentiation of B cells into macrophages induced by C/EBPα is fully efficient and initiated al...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-46321 | biostudies-arrayexpress
Models,MultiomicsLymphoid and myeloid cell specification and transdifferentiation
Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental process is controlled by a complex regulatory network involving cytokines and...
8186 | Cell Collective
UnknownNew Immunohistochemical Markers for Pleural Mesothelioma Subtyping.
Not available
S-EPMC10529020 | biostudies-literature
UnknownTransposable element activity captures human pluripotent cell states
Not available
S-SCDT-10_1038-S44319-024-00343-Y | biostudies-other
GenomicsHow C/EBPa creates an elite cell state for reprogramming to pluripotency [ChIPseq]
Mouse Bcell, upon ectopic expression of the transcription factor Cebpa for 18h, can be reprogrammed to iPS with extremely high efficiency. To understand the molecular control of this phenomena we performed multiple high throughtput functionnal genomic analysis. Genome binding/occupancy of transcript...
ORGANISM(S): Mus musculus 
2016-02-19 | E-GEOD-71215 | biostudies-arrayexpress
TranscriptomicsHow C/EBPa creates an elite cell state for reprogramming to pluripotency [RNAseq]
Mouse Bcell, upon ectopic expression of the transcription factor Cebpa for 18h, can be reprogrammed to iPS with extremely high efficiency. To understand the molecular control of this phenomena we performed multiple high throughtput functionnal genomic analysis. Transcriptomic by RNAseqencing (polyA+...
ORGANISM(S): Mus musculus 
2016-02-19 | E-GEOD-71217 | biostudies-arrayexpress
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