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GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
ProteomicsProtection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-14 | PXD031972 | Pride
Sq motifs Rif1 Dsb resection inhibition Dna replication fork protection Intrinsically disordered region 
GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
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