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ProteomicsIntestinal metaproteomics reveals host-microbiota interactions in subjects at risk for type 1 diabetes
Dysbiosis of the gut microbiota has been linked to disease pathogenesis in type 1 diabetes (T1D), yet the functional consequences to the host of this dysbiosis is unknown. Here, we have performed a metaproteomic analysis of 103 stool samples from subjects that either had recent-onset T1D, were high-...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD008870 | Pride
Diabetes metaproteome 
ProteomicsStool metaproteomics of children with islet autoimmunity
The gastrointestinal ecosystem is a highly complex environment with a profound influence on human health. Inflammation in the gut, linked to an altered gut microbiome has been associated with the development of multiple human conditions including type 1 diabetes (T1D). Viruses infecting the gastroin...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD032997 | Pride
T1d metaproteome 
ProteomicsMetabolic reconfiguration through SGLT2 inhibition improves metabolic waste excretion
Dapagliflozin is a member of a new class of medication called gliflozins indicated for the treatment of diabetes and has recently been also approved for the treatment of kidney and heart diseases. Gliflozins lower blood glucose levels by inhibition of the sodium glucose co-transporter 2 (SGLT2), whi...
ORGANISM(S): Mus musculus (Mouse) mouse gut metagenome 
2026-02-09 | PXD036817 | Pride
White adipose tissue Kidney Heart Skeletal muscle Lc-ms/ms Dapagliflozin Mouse Tmt Exploris 480 Murine Sglt2 inhibitors Liver Gut microbiome 
UnknownAssociations of the Fecal Microbial Proteome Composition and Proneness to Diet-induced Obesity.
Not available
S-EPMC6731084 | biostudies-literature
UnknownMulti-omic interactions in the gut of children at the onset of islet autoimmunity.
Not available
S-EPMC9756488 | biostudies-literature
Genomics
Fecal microbiome of children with islet autoimmunity
PRJNA822783 | ENA
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