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MetabolomicsUntargeted Metabolomic Profiling of Left Ventricular Myocardium in a Mouse Model of Diabetic Cardiomyopathy
This study characterizes metabolic alterations in the left ventricular myocardium of a high-fat diet and streptozotocin-induced mouse model of diabetic cardiomyopathy. Untargeted LC–MS/MS metabolomics was performed using a Vanquish UHPLC system coupled to an Orbitrap Exploris 120 mass spectrometer. ...
2026-07-20 | MTBLS15043 | MetaboLights
MetabolomicsGut Microbiota-Derived Indole-3-Propionic Acid Ameliorates Diabetic Cardiomyopathy by Regulating Mitochondrial Dynamics via the AhR/Nrf2 Pathway
This study investigated serum metabolic alterations in a mouse model of diabetic cardiomyopathy and evaluated the protective role of the gut microbiota-derived metabolite indole-3-propionic acid. Serum samples from mice were analyzed using untargeted LC-MS metabolomics. The study focused on the rela...
2026-07-26 | MTBLS14953 | MetaboLights
MetabolomicsRetinol Dehydrogenase 10 Reduction Mediated Retinol Metabolism Disorder Promotes Diabetic Cardiomyopathy in Male Mice.
Not available
ORGANISM(S): Mus musculus 
ST002474 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of rat ventricle samples from streptozotocin (STZ)-diabetic animals to investigate mitochondrial long-chain free fatty acid export
Cardiomyopathy in type 1 diabetic patients is characterized by early onset diastolic and late onset systolic dysfunction. The mechanism underlying development of diastolic and systolic dysfunction in diabetes remains unknown. We used microarrays to detail the ventricle gene expression changes that ...
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-4745 | biostudies-arrayexpress
ProteomicsProteomics analyses reveal the novel targets of spermine alleviating diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is one of the most serious complications of diabetes. Recent cardiology studies suggest that spermine has cardioprotective effect. Here, we used proteomics analyses to reveal the underlying research target in type 2 diabetic mouse model treated with spermine. Left ventr...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD036364 | Pride
Diabetic cardiomyopathy  spermine  proteomic analysis  bioinformatic db/db mouse 
GenomicsMETTL3 in Diabetic Cardiomyopathy
METTL3 in Diabetic Cardiomyopathy
PRJNA1057185 | ENA
ProteomicsProteomic Analysis insights into Potential Mechanism of SGLT2 Inhibitors cardiovascular benefit in Diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is one of the major causes of heart failure in diabetic patients, but its pathogenesis remains unclear. Sodium glucose cotransporter 2 inhibitors (SGLT2i) can effectively reduce the risk of cardiovascular death and heart failure in DCM patients, but the underlying mecha...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD036090 | Pride
Sglt2 inhibitors Diabetic cardiomyopathy Proteomics 
ProteomicsTitle Page Cardiac Gene Therapy Rescues Diabetic Cardiomyopathy and Lowers Blood Glucose
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intra-cardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes induced H...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044236 | Pride
Calcium handling Transverse-tubule microdomain Gene therapy Glucose uptake Diabetic cardiomyopathy 
ProteomicsEarly cardiomyopathy in prediabetic NDPK-B-deficient mice is associated with remodeling of the mitochondrial O-GlcNAc proteome
Diabetic cardiomyopathy (DCM) is characterized by myocardial remodeling that may already be evident during prediabetes, yet the molecular alterations accompanying these early changes remain poorly understood. The present study examined mouse models of Nucleoside diphosphate kinase (NDPK-B)-deficient...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-21 | PXD081812 | Pride
Prediabetes  diabetes  ndpk-b  hbp  diabetic cardiomyopathy  mitochondria 
Proteomicsβ-Hydroxybutyrylation in Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM) is characterized by metabolic remodeling and energetic stress independent of coronary artery disease. Increased reliance on fatty acid and ketone body metabolism has been observed in DCM, but the regulatory mechanisms linking altered substrate utilization to myocardial ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD066713 | Pride
Diabetic cardiomyopathy  β-hydroxybutyrylation (kbhb)  metabolic remodeling  ketone body metabolism  mitochondrial regulation 
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