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ProteomicsDapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis
Male infertility is one of the most common complications of diabetes mellitus (DM). Dapagliflozin is widely used to manage the type II DM. This study aimed to assess the dapagliflozin’s effects on the spermatogenesis by administering either dapagliflozin (Dapa) or a vehicle (db) to diabetic male db/...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-04 | PXD034622 | Pride
Diabetic male infertility  dapagliflozin  gut microbiota  metabolites  testicular protein expression 
TranscriptomicsUrinary bladder disease in rat experimental diabetes mellitus
Diabetes mellitus (DM) is a leading cause of chronic kidney disease and the pathobiology of diabetic nephropathy is widely studied. Less, however, is known about urinary bladder disease in DM despite dysfunctional voiding being a common clinical problem. We hypothesised that diabetic cystopathy woul...
ORGANISM(S): Rattus norvegicus 
2021-07-17 | E-MTAB-9255 | biostudies-arrayexpress
TranscriptomicsGene Expression from diabetic ischemic limbs in WT and p75KO mice
Transcriptome analysis was carried out to characterise the different responses of diabetic and non-diabetic WT and p75KO mice to ischemia C57BL/6J-p75NTR-/- (p75KO) and p75NTR+/+ (WT) littermates were bred starting from breeding pairs. Six to seven week old male p75KO and WT mice were made diabetic...
ORGANISM(S): Mus musculus 
2011-12-24 | E-GEOD-34675 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) isolated from patients in secondary prevention of CVD taking placebo, grape extract or resveratrol-enriched grape extract
We used Affymetrix microarrays to investigate gene expression changes in PBMCs isolated from male patients ongoing secondary prevention of CVD to determine significant modulatory effects that may have been induced by the intake of an initial dose of 8 mg of resveratrol-enriched grape extract for 6 m...
ORGANISM(S): Homo sapiens 
2012-06-29 | E-GEOD-36930 | biostudies-arrayexpress
UnknownAssessing the Efficacy of Acanthoic Acid Isolated from Acanthopanax koreanum Nakai in Male Infertility: An In Vivo and In Silico Approach.
Not available
S-EPMC11276288 | biostudies-literature
UnknownSalazinic acid attenuates male sexual dysfunction and testicular oxidative damage in streptozotocin-induced diabetic albino rats.
Not available
S-EPMC10132129 | biostudies-literature
UnknownTransgenerational inheritance of susceptibility to diabetes-induced male subfertility.
Not available
S-EPMC5504044 | biostudies-literature
UnknownGynura procumbens Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic.
Not available
S-EPMC6186343 | biostudies-literature
TranscriptomicsIn vivo gene expression changes in EW5 Ewing sarcoma xenografts after IGF-1R or mTOR blockade
Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pat...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-67529 | biostudies-arrayexpress
UnknownInflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis.
Not available
S-EPMC12665571 | biostudies-literature
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