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ProteomicsProteomic analysis of meningiomas reveals clinically-distinct molecular patterns
Meningiomas represent one of the most common and clinically heterogeneous brain tumor types that only modestly correlate with histopathologic features. While emerging molecular profiling efforts have linked specific genomic drivers to distinct clinical patterns, the proteomic landscape of meningioma...
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD012923 | Pride
Meningiomas Neuro-oncology Mass spectrometry Stratification Proteome 
ProteomicsShifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Rett Syndrome Neurons
Translation of many transcripts is highly regulated in the developing brain, and disturbance of translational regulation machinery contributes to neurodevelopmental disorders. In neural progenitor cells, for example, several critical pro-differentiation genes are transcribed, but their translation i...
ORGANISM(S): Homo sapiens (Human) 
2020-05-07 | PXD011961 | Pride
Rnaseq Rett syndrome Ms proteomics 
ProteomicsAn anatomic proteomic atlas of human glioblastoma
Glioblastoma (GBM) is an aggressive form of brain cancer with well-established patterns of intra-tumoral heterogeneity implicated in treatment resistance, recurrence and progression. While the regional and single cell-level genetic variation of GBM have been recently resolved, downstream phenotype-l...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD019381 | Pride
Glioblastoma Laser capture microdissection Anatomical niches Lc-ms/ms 
ProteomicsHAVOC: Small-scale histomic mapping of biodiversity across entire tumor specimens using deep neural networks
Intra-tumoral heterogeneity can wreak havoc on current precision medicine strategies due to challenges in sufficient sampling of geographically separated areas of biodiversity distributed across centimeter-scale tumor distances. In particular, modern tissue profiling approaches are still largely des...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD037548 | Pride
Molecular profiling Tumor heterogeneity Computer vision Artificial intelligence Deep learning 
ProteomicsTopographic mapping of the glioblastoma proteome reveals a triple axis model of intra-tumoral heterogeneity
Glioblastoma (GBM) is an aggressive form of brain cancer with well-established patterns of intra-tumoral heterogeneity implicated in treatment resistance, recurrence and progression. While regional and single cell transcriptomic variations of GBM have been recently resolved, downstream phenotype-lev...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD029290 | Pride
Proteomics Gbm Mass spectrometry 
ProteomicsConserved proteomic programs between human cerebral tissue and organoids implicate RUVBL2 in neurodevelopment and disease
Cerebral organoids have emerged as faithful humanoid avatars for modeling numerous advanced neurodevelopmental and pathological processes and additionally serve as a powerful discovery platform for less well-characterized neurobiological programs. Towards this later prospect, we leveraged mass spect...
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD028911 | Pride
Neurodevelopment Proteomics Mass spectrometry Cerebral organoids 
ProteomicsRegionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment
Cerebral organoids have emerged as faithful humanoid avatars for modeling neurodevelopmental and pathological processes. Additionally, they serve as powerful discovery platforms for less characterized neurobiological programs. Towards this prospect, we leveraged mass spectrometry-based proteomics to...
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD033012 | Pride
Proteomics Neurodevelopment Mass spectrometry 
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