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MetabolomicsCryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues
OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS boosts ioni...
2023-03-15 | MTBLS1873 | MetaboLights
UnknownApplication of super-resolution and correlative double sampling in cryo-electron microscopy.
Not available
S-EPMC9642007 | biostudies-literature
UnknownRefinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.
Not available
S-EPMC4854230 | biostudies-literature
UnknownCorrelation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Not available
S-EPMC9351521 | biostudies-literature
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
UnknownThe antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.
Not available
S-EPMC8626228 | biostudies-literature
UnknownA potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Not available
S-EPMC8458290 | biostudies-literature
GenomicsExtensive characterization of NF-kappaB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits
We report the DNA binding preferences of 4 NF-kappaB dimers (p52p52, RELARELA, RELAp50, RELAp52) Proteins of the Nf-kappab family were bound to DNA oligonucleotides containing a degenerate region. The protein-DNA complexes were selected after one or multiple rounds of SELEX and the DNA molecules w...
ORGANISM(S): Homo sapiens 
2011-05-24 | E-GEOD-29460 | biostudies-arrayexpress
UnknownLow-dose phase retrieval of biological specimens using cryo-electron ptychography.
Not available
S-EPMC7265480 | biostudies-literature
TranscriptomicsTranscription profiling of Strongyloides ratti larval stage 1 (L1) vs infective larval stage 3 (iL3)
Isofemale line ED321 Heterogonic was used. Fresh faeces were collected from S. ratti-infected rats at days 5, 6, 7 and 8 p.i. and L1s prepared with a Baermann funnel held for 6 h at 19oC. The larvae were concentrated by centrifugation and then cleaned by flotation on 60% v/v sucrose. Infective L3s w...
ORGANISM(S): Strongyloides ratti 
2022-11-21 | E-MEXP-697 | biostudies-arrayexpress
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