Sort   by:  
 Page size 
ProteomicsDefinition of the Dicer-2 interactome during viral infection in Drosophila melanogaster
Although many in vitro studies have helped us understand how Dicer-2 is able to discriminate between different dsRNA substrate termini, much less is known about how this translates to the in vivo recognition of viral dsRNA. Indeed, Dicer-2 associates with several dsRNA-binding proteins (dsRBPs), whi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-15 | PXD038898 | Pride
Innate immunity Antiviral Dicer-2 Drosophila c virus 
TranscriptomicsEndogenous short RNAs in Mucor circinelloides sequenced on the Illumina platform (Solexa)
We sequenced Endogenous short RNAs in Mucor circinelloides fungus grown in standard liquid culture. Short RNAs were profiled in wild type, Dicer-like 1 mutant (dcl1-), Dicer-like 2 mutant (dcl2-) and double Dicer mutant (dcl1-/dcl2-) strains. We identified many loci that produced less short RNAs in ...
ORGANISM(S): Mucor circinelloides 
2010-04-28 | E-GEOD-18958 | biostudies-arrayexpress
ProteomicsStructural insights into dsRNA processing by Drosophila Dicer-2/Loqs-PD
Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA silencing mechanism in many eukaryotes. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided by its cofactor Loquacious-PD (Loqs-PD), plays major role in generating 21 base-pair (bp) siRNA duplex...
ORGANISM(S): Drosophila Melanogaster 
2022-04-21 | PXD033365 |
ProteomicsDrosophila early embryos LC-MSMS
Cytoplasmic polyadenylation is a mechanism to promote mRNA translation in a wide variety of biological contexts.The conserved RNA-binding protein family CPEB has been shown to mediate canonical cytoplasmic polyadenylation of target transcripts. We have previously reported evidence for RNA-interferen...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-08-30 | PXD030281 | Pride
Lc-msms Early embryos Drosophila Dicer-2 
Genomicssmall RNAs produced in the mutant Dicer-2 transgenic flies
small RNAs produced in the mutant Dicer-2 transgenic flies
PRJNA374414 | ENA
TranscriptomicsDiverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi
A variety of small RNAs, including the Dicer-dependent miRNAs and the Dicer-independent Piwi-interacting RNAs, associate with Argonaute family proteins to regulate gene expression in diverse cellular processes. These two species of small RNA have not been found in fungi. Here, by analyzing small RN...
ORGANISM(S): Neurospora crassa 
2010-07-01 | E-GEOD-21175 | biostudies-arrayexpress
TranscriptomicsA microRNA-directed program of cytotoxic CD8+ T cell differentiation
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTL, and that deletion or depletion of Dicer in mouse or human activated CD8+ T cells causes upregulation of perforin, granzyme an...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-51393 | biostudies-arrayexpress
GenomicsAtaxin-2, Twenty-four and Dicer-2 are components of a non-canonical cytoplasmic polyadenylation complex
Ataxin-2, Twenty-four and Dicer-2 are components of a non-canonical cytoplasmic polyadenylation complex
PRJNA784931 | ENA
Genomicssmall RNAs produced in the wild-type and mutant Dicer-2 transgenic flies
small RNAs produced in the wild-type and mutant Dicer-2 transgenic flies
PRJNA329574 | ENA
TranscriptomicsThe profiling of gene expression in pupa stage of Drosophila melanogaster: Wildtype vs. dicer-2 mutant
To investigate transcriptional effects caused by a severe defect in endo-siRNA production, a gene expression profiling was performed on Drosophila dicer-2 pupae compared to wild-type. Two-condition experiment, Wildtype pupa vs. dicer-2 mutant pupa. Biological replicates: each 3 replicates.
ORGANISM(S): Drosophila melanogaster 
2012-05-20 | E-GEOD-35945 | biostudies-arrayexpress
Sort   by:  
 Page size