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ProteomicsAnalysis of the impact of DICER1 and DROSHA on the angio-genic capacity of human endothelial cells
RNAi-mediated knockdown of DICER1 and DROSHA, enzymes critically involved in miRNA biogenesis, has been postulated to affect the homeostasis and the angiogenic capacity of human endothelial cells. To re-evaluate this issue, we reduced the expression of DICER1 or DROSHA by RNAi-mediated knockdown and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027923 | Pride
Endothelial cells  angiogenesis  microrna biogenesis Dicer1  drosha  rna interference 
ProteomicsProximity Proteomics Revealed Dicer1 and Transporters as Client Proteins of Aha1
Co-chaperone Aha1 activates HSP90 ATPase to promote the folding of client proteins. However, the client proteins of Aha1 are largely unknown. By employing ascorbate peroxidase (APEX) based proximity labeling, we identified 32 proximity proteins of HSP90 that are modulated by genetic depletion of Aha...
ORGANISM(S): Pan troglodytes (Chimpanzee) Homo sapiens (Human) 
2022-11-19 | PXD028980 | Pride
Hsp90 Dicer1 Apex Proximity labeling Aha1 
TranscriptomicsRNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55377 | biostudies-arrayexpress
TranscriptomicsDicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice
MiRNAs have the potential to regulate cellular differentiation programs. However, miRNA-deficiency in primary hematopoietic stem cells (HSCs) results in HSC depletion in mice, leaving the question of whether miRNAs play a role in early-lineage decisions unanswered. To address this issue, we deleted ...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-35844 | biostudies-arrayexpress
Transcriptomicssmall RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55376 | biostudies-arrayexpress
ProteomicsDICER1 syndrome-associated mutations lead to 3p-miRNA gain of function and increased metastatic potential
The DICER1 gene is mutated in cancer, including Dicer1 syndrome, a rare tumour predisposition syndrome. Cancer-associated hotspots mutations have been reported in both catalytic domains of Dicer, and are predicted to disrupt miRNA processing activity. To understand these hotspot mutations in cancer ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD072167 | Pride
Cancer Dia Dicer1 Mutations Exploris480 
UnknownHematologic indices in individuals with pathogenic germline DICER1 variants.
Not available
S-EPMC7805337 | biostudies-literature
UnknownDICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
Not available
S-EPMC8695383 | biostudies-literature
UnknownNeoplasm Risk Among Individuals With a Pathogenic Germline Variant in DICER1.
Not available
S-EPMC6553836 | biostudies-literature
GenomicsConditional DICER1 knockout hESCs
Conditional DICER1 knockout hESCs
PRJNA450977 | ENA
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