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ProteomicsExploris 480 dataset acquired on a human fecal standard to evaluate metaproteomics strategies.
Metaproteomics of a human fecal standard, MetaP, with an Exploris480 tandem mass spectometer operated in data-dependent analysis for proteotyping and evaluation of metaproteomics strategies.
ORGANISM(S): Homo sapiens (Human) Balneola vulgaris Deinococcus proteolyticus MRP 
2024-03-07 | PXD047139 | Pride
Metaproteomics Proteins Functional analysis Microbiome Gut Proteotyping Taxa 
ProteomicsEpisodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation
To generate this dataset, different proteins (human HDAC6, CCT8, 26S proteasome, Hsc70, Hsp90, p62, and Xenopus HOOK2 were immunoprecipitated from the Hela S3 cell extract or Xenopus egg extract by the Dynabeads Protein G beads (Thermo Fisher, #10004D) coated with corresponding primary antibodies as...
ORGANISM(S): Homo sapiens (Human) 
2025-07-16 | PXD054601 | Pride
Lc-ms Ip 
ProteomicsDifferential role of phosphorylation in glucagon family receptor signaling revealed by mass spectrometry (TEV cleavage middle down samples)
These are the .raw files from Exploris480 used to examine C-tail phosphorylation in GPCRs using middle-down proteomics.
ORGANISM(S): Homo Sapiens (human) 
2025-04-07 | PXD060260 | JPOST Repository
ProteomicsIntegrating endometrial proteomic and single cell transcriptomic pipelines reveals distinct menstrual cycle and endometriosis-associated molecular profiles
Endometriosis is a debilitating gynecological disorder affecting approximately 10% of the female population. Despite its prevalence, robust methods to classify and treat endometriosis remain elusive. Changes throughout the menstrual cycle in tissue size, architecture, cellular composition, and indiv...
ORGANISM(S): Homo sapiens (Human) 
2023-09-05 | PXD045115 | Pride
Endometriosis Thermo orbitrap exploris480 Lc-ms/ms 
ProteomicsELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation
Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA lesions. DNA damage-induced binding of the TCR-specific repair factor CSB to RNA polymerase II (RNAPII) triggers RNAPII ubiquitylation at a single lysine (K1268) by the CRL4CSA ubiquitin ligase. How CRL4CSA is sp...
ORGANISM(S): Homo sapiens (Human) 
2021-04-21 | PXD024051 | Pride
Tc-ner Rna polymerase ii Dna repair. Transcription 
ProteomicsSustained PRC1.1 activity preserves gene repression independent of PRC2.2 and suppresses leukemic cell differentiation
Loss-of-function mutations in BCOR, subunit of the non-canonical Polycomb Repressive Complex 1.1 (PRC1.1), are frequently observed in acute myeloid leukemia (AML) and associate with adverse risk, but underlying mechanisms driving leukemogenesis remain elusive. Here, we find that BCOR is a bridging f...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD065157 | Pride
Human Exploris480 
ProteomicsRB1 mass spec with or without MYC amplification
293T cells were transfected with Flag-tagged RB1 with or without MYC. After 48 h, the cells were lysed with IP buffer and immunoprecipitated with Flag-conjugated agarose beads (Sigma-Aldrich). The bound proteins were eluted with 2% SDS and digested overnight with sequencing grade modified trypsin (P...
ORGANISM(S): Homo Sapiens 
2022-10-17 | PXD037479 |
ProteomicsDICER1 syndrome-associated mutations lead to 3p-miRNA gain of function and increased metastatic potential
The DICER1 gene is mutated in cancer, including Dicer1 syndrome, a rare tumour predisposition syndrome. Cancer-associated hotspots mutations have been reported in both catalytic domains of Dicer, and are predicted to disrupt miRNA processing activity. To understand these hotspot mutations in cancer ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD072167 | Pride
Cancer Dia Dicer1 Mutations Exploris480 
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Aflatoxin B1 (AFB1)-induced hepatic inflammation poses severe global health burdens with limited interventions. Here, we demonstrated that ferulic acid (FA), a cereal-derived polyphenol, alleviated AFB1 hepatotoxicity by remodeling gut microbiota and activating microbial tryptopha...

2026-08-14 | MTBLS12942 | MetaboLights
ProteomicsIn-source CID improves HCD-dependent fragmentation of ADP-ribosyl peptides
ADP-ribosylation is a posttranslational modification whose HCD products are dominated by complete or partial modification losses, complicating peptide sequencing and acceptor site localization efforts. We tested whether in-source CID performed on a quadrupole Orbitrap could convert ADPr to the small...
ORGANISM(S): Homo sapiens (Human) 
2024-12-05 | PXD055586 | Pride
Sid Proteomics Hcd Exploris480 Adp-ribosylation 
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