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TranscriptomicsDNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes
The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction ...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress
GenomicsElf1 promotes TC-NER in yeast by using its C-terminal domain to bind TFIIH
Elf1 promotes TC-NER in yeast by using its C-terminal domain to bind TFIIH
PRJNA1018995 | ENA
OtherElf1 promotes TC-NER in yeast by using its C-terminal domain to bind TFIIH
Transcription coupled-nucleotide excision repair (TC-NER) repairs DNA lesions that stall RNA polymerase II (Pol II) transcription. Here, we show that the C-terminal domain (CTD) of elongation factor-1 (Elf1) plays a critical role in TC-NER in yeast. Analysis of genome-wide repair of UV-induced cyclo...
ORGANISM(S): Saccharomyces cerevisiae 
2024-05-31 | GSE243603 | GEO
ProteomicsDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD051638 | Pride
Crl4csa Rna polymerase ii Dna damage Dda1 Transcription-coupled repair 
ProteomicsTRiC controls transcription resumption after UV damage by regulating Cockayne Syndrome protein A
Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA polymerase II at DNA lesions, leading to the recruitment of TC-NER-specific factors such as the CSA-DDB1-CUL4A-RBX1 culli...
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008868 | Pride
Csa Tric Tc-ner 
ProteomicsTranscription-coupled DNA-Protein Crosslink repair by CSB and CRL4(CSA)-mediated degradation
DNA-protein crosslinks (DPCs), arise from enzymatic intermediates, endogenous metabolism or exogenous chemicals like chemotherapeutics. DPCs are highly cytotoxic as they will impede DNA transacting processes such as replication, which is counteracted by proteolysis-mediated DPC removal by the protea...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2024-02-09 | PXD041679 | Pride
Tc-ner Silac Csb Csa 
TranscriptomicsMPA and NQO studies (Sevilla)
RNA polymerases deal with obstacles during transcription elongation that need to be removed. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TCR). To improve our knowledge of transcription elongation and its coupling to TCR, we performed DN...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-29 | E-GEOD-11561 | biostudies-arrayexpress
ProteomicsResidual CSB activity explains UVSS caused by CSB mutations
Transcription-Coupled Nucleotide Excision Repair (TC-NER) preserves transcriptional integrity by repairing transcription-blocking lesions (TBLs), which are highly cytotoxic if left unresolved. TC-NER is initiated when RNA Polymerase II (Pol II) stalls at a lesion and is recognized by CSB, followed b...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD074100 | Pride
Transcription-coupled nucleotide excision repair (tc-ner) Uvss Csb 
GenomicsHomo sapiens
RNA polymerase IIo ChIP-seq by employing the K1268R RPBI mutant and TC-NER deficient HeLa cells
PRJNA548234 | ENA
UnknownStudies on the functionality of the TC-NER ERCC6-M1097V protein variant frequently found in Louisiana patients with PCa upon UV damage.
Not available
S-EPMC12909189 | biostudies-literature
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