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ProteomicsNuclear TRiC states captured in situ
The chaperonin T-complex protein ring complex (TRiC) is an essential protein-folding machine in eukaryotic cells. Although its cytosolic role in folding newly synthesized proteins is well established, nuclear TRiC remains less well described. Here, we combined cryo-electron tomography (cryo-ET), cro...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD083885 | Pride
Ap-ms Cryo-et Tric complex 
ProteomicsChaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella
As animals evolved from external to internal fertilization, sperm flagella, which once transiently propelled sperm in water to reach nearby eggs, developed to beat for days or even longer within the female reproductive tract. How flagella were remodeled accordingly remains unclear. Unlike externally...
ORGANISM(S): Bos Taurus 
PXD067693 |
ProteomicsCross-linking coupled with mass spectrometry (XL-MS) analysis of TRiC-PDCD5 complex
In order to investigate the interaction between TRiC and PDCD5 proteins, purified PDCD5 and TRiC were incubated for XL-MS analysis. A total of 1094 cross-linked peptides were identified.
ORGANISM(S): Mus musculus (Mouse) 
2026-01-08 | PXD068864 | Pride
Tric Pdcd5 Proteomics Cross-linking 
ProteomicsTRiC controls transcription resumption after UV damage by regulating Cockayne Syndrome protein A
Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA polymerase II at DNA lesions, leading to the recruitment of TC-NER-specific factors such as the CSA-DDB1-CUL4A-RBX1 culli...
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008868 | Pride
Csa Tric Tc-ner 
GenomicsRound or columnar and hypertrophic chondrocytes of Tric-b-KO mice
Round or columnar and hypertrophic chondrocytes of Tric-b-KO mice
PRJNA928352 | ENA
GenomicsTRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [DNase-Seq]
TRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [DNase-Seq]
PRJNA1146452 | ENA
GenomicsTRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [RNA-seq]
TRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [RNA-seq]
PRJNA1146450 | ENA
GenomicsTRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [4tU-Seq]
TRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [4tU-Seq]
PRJNA1146451 | ENA
OtherTRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [DNase-Seq]
The molecular chaperonin TRiC/CCT is a large hetero-oligomeric structure that serves an essential role in eukaryotic cells by minimally supporting protein homeostasis including the folding of nascent polypeptides and the assembly/disassembly of protein complexes. TRiC/CCT is typically considered a s...
ORGANISM(S): Saccharomyces cerevisiae 
2025-09-01 | GSE274455 | GEO
TranscriptomicsTRiC/CCT Chaperonin Regulates RNA Polymerase II in the Nucleus [4tU-Seq]
The molecular chaperonin TRiC/CCT is a large hetero-oligomeric structure that serves an essential role in eukaryotic cells by minimally supporting protein homeostasis including the folding of nascent polypeptides and the assembly/disassembly of protein complexes. TRiC/CCT is typically considered a s...
ORGANISM(S): Saccharomyces cerevisiae 
2025-09-01 | GSE274454 | GEO
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