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UnknownCln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration.
Not available
S-EPMC9012467 | biostudies-literature
UnknownClinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy.
Not available
S-EPMC11587193 | biostudies-literature
UnknownEndothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
Not available
S-EPMC7334103 | biostudies-literature
UnknownStructure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.
Not available
S-EPMC7854729 | biostudies-literature
UnknownZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome.
Not available
S-EPMC10618915 | biostudies-literature
UnknownAntiviral evaluation of hydroxyethylamine analogs: Inhibitors of SARS-CoV-2 main protease (3CLpro), a virtual screening and simulation approach.
Not available
S-EPMC8416325 | biostudies-literature
TranscriptomicsMethionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.
We investigated the effect of methionine sulfoximine (MetSox), a potent inhibitor of glutamine synthetase, on Mycobacterium tuberculosis. M. tuberculosis encodes four glutamine synthetases, of which MetSox targets the type I enzyme encoded by glnA1. Trancriptional profiling revealed that glutamate s...
ORGANISM(S): Mycobacterium tuberculosis 
2011-09-06 | E-BUGS-112 | biostudies-arrayexpress
ProteomicsIL7R mutational activation can initiate Ph-like and PAX5 P80R precursor B-cell acute lymphoblastic leukemia
Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological level...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD017147 | Pride
Acute lymphoblastic leukemia B cells 
MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
TranscriptomicsA comparative transcriptomics approach unveils networks of activity-driven neuronal gene expression
Primary cultured hippocampal neurons were infected with lentiviral particles bearing constitutively active versions of the transcription factors CREB, SRF, EGR1 and FOS to define the downstream genetic program associated with each of these paradigmatic transcription factors in neurons. For CREB, we ...
ORGANISM(S): Mus musculus 
2011-11-19 | E-MEXP-3167 | biostudies-arrayexpress
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