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ProteomicsTwo related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through two different acetyltransferase-independent mechanisms
SAGA and ATAC are two related transcriptional coactivator complexes, sharing the same histone acetyltransferase (HAT) subunit. The HAT activities of SAGA and ATAC are required for metazoan development but the precise role of the two complexes in RNA polymerase II transcription in mammals is less und...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-11 | PXD027026 | Pride
Saga Newly synthesized rna Histone acetyltransferase 4su labelling Atac Pol ii transcription Hat-independent function Mouse embryonic stem cells Coactivator complexes 
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription
This SuperSeries is composed of the SubSeries listed below. The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wi...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-29 | E-GEOD-59370 | biostudies-arrayexpress
ProteomicsSUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells
Co-activator complexes regulate chromatin accessibility and transcription. SAGA (Spt-Ada-Gcn5 Acetyltransferase) is an evolutionary conserved multisubunit co-activator complex with modular organization. The core module of SAGA constitutes the structural heart, composed of a histone octamer like stru...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-07-26 | PXD026991 | Pride
Elisabeth scheer Didier devys Damien plassard Elisabeth lata bastian morlet And lászló tora Veronique fischer Stéphane d. vincent 
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [Yeast cells]
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-29 | E-GEOD-52997 | biostudies-arrayexpress
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [HeLa cells]
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon ...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-52860 | biostudies-arrayexpress
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