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Transcription profiling by array (2)

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Division of Cancer Research, Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Germany (1)

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In vivo RNA Affinity Purification of wildtype and nonstop mutant VHL tumor suppressor mRNA

Nonstop extension or stop-loss mutations in the von Hippel Lindau (VHL) tumor suppressor gene are recurrently found in kidney cancer patients as observed from the NonStopDB database. We observed that presence of this nonstop extension mutation caused loss of the protein via the ubiquitin-proteasome ...

ORGANISM(S): Homo sapiens (Human)

2025-05-07 | PXD053175 | Pride

microRNA Profiling in Wilms Tumors and Kidney Tissues

The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bea...

ORGANISM(S): Homo sapiens

2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress

The concept of "RNA dependence" - Proteome-wide and quantitative identification of protein interactions dependent on RNA

The general role of RNA in the cell beyond protein biosynthesis is only beginning to emerge with little knowledge about the structural or organizational functions of RNA. In turn, functional non-coding RNAs (ncRNAs) are often identified by their regulation or impact on cellular phenotypes. However, ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2018-06-13 | MSV000082468 | MassIVE

Genes affected by manipulation of LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer

The long non coding RNA LIMT was found in our study to inhibit cellular migration in vitro and to inhibit colonization of mammary tumorigenic cells in lungs of mice in vivo. In order to uncover the mechanism enabling these tumor suppressive functions of LIMT the expression of this lncRNA was knocked...