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MetabolomicsMass Spectrometry Imaging of Lipids in a Gut Epithelial Cell Model

Scope: The Caco2/HT29-MTX co-culture system is widely used as a cell model of the intestinal epithelium. Although the gut epithelium plays an important role in the uptake of free fatty acids and the resynthesis of triglycerides, the lipid distribution profile of the two-dimensional co-culture sys...

2025-06-14 | MTBLS12599 | MetaboLights
TranscriptomicsTranscription profiling by array of rat mammary glands to study the effects of dietary lipids
Nutritional factors may have a role on the susceptibility of the mammary gland malignant transformation. Here we study the role dietary lipids on development and gene expression profile of Sprague-Dawley rat mammary gland
ORGANISM(S): Rattus norvegicus 
2020-03-04 | E-MTAB-3530 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse PPARalpha knockouse to investigate TPPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
Background: The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called ‘intestinal barrier proteins’. An important receptor that mediates the effects of dietary lipids on g...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-9533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human enterocytes cultured with different dietary lipids
The present study aimed to identify the specific impact of dietary lipids-containing micelles on gene expression in enterocytes.
ORGANISM(S): Homo sapiens 
2008-08-27 | E-MEXP-1446 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat experimental tumours to study the effects of dietary lipids
Nutritional factors may have a role on mammary carcinogenesis. Here we study the role dietary lipids on gene expression profile of DMBA-induced mammary tumors in Sprague-Dawley rats
ORGANISM(S): Rattus norvegicus 
2018-11-21 | E-MTAB-3541 | biostudies-arrayexpress
MetabolomicsDietary carbohydrate and protein levels affect the growth performance of juvenile peanut worm (Sipunculus nudus): an LC–MS-based metabolomics study
The peanut worm (Sipunculus nudus) is an economically important fishery resource in China. To determine how dietary carbohydrate and protein levels affects the growth performance of juvenile S. nudus and identify the mechanisms underlying observedpatterns, five isoenergetic and isolipidic diets with...
2021-07-16 | MTBLS2887 | MetaboLights
MetabolomicsMouse Brown Adipose Tissue Lipidomics under Cold and Dietary Fat Interventions
This study investigates lipidomic remodeling in mouse brown adipose tissue under a 2 × 3 experimental design involving environmental condition and dietary fatty acid composition. Mice were maintained at room temperature with ad libitum feeding or exposed to 4°C cold conditions with 70% calorie restr...
2026-06-01 | MTBLS14642 | MetaboLights
MetabolomicsHuman milk as infantile Super Food - the effect of dietary choices and supplementation on the shift of lipidomic profile during different stages of lactation
The objective of this project was to establish an advanced analytical method leveraging high-resolution mass spectrometry LC-HRMS to comprehensively profile the human milk lipidome. Mass spectrometry resolves and quantifies compounds based on a fundamental physical metric: the mass-to-charge ratio. ...
2026-09-22 | MTBLS15678 | MetaboLights
TranscriptomicsModification of miRNA profile in Caco-2 cells by dietary lipids
The aim of this study was to detect miRNAs modified by biactive dietary lipids in a cellular model of enterocytes. The selected model was Caco-2 cells Differentiated Caco-2 cells were incubated with micelles containing the lipids for 24 and 48 hours. The expression leveles of the miRNAs were compare...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-59153 | biostudies-arrayexpress
MetabolomicsThe microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the gut
Gut microbiomes play a key role in the maintenance of host metabolic homeostasis and health. An important aspect of metabolism is its circadian regulation, but how the microbiome regulates metabolite cycling under different conditions, including variations in dietary composition, remains undefined. ...
2025-04-08 | MTBLS8819 | MetaboLights
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