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TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator [ChIP-chip]
The L-Mediator is a general co-activator of RNA Polymerase II transcription and is formed by the reversible association of the S-Mediator and the kinase module harbouring Cdk8. We describe the Cdk11-Lcp1 complex and show that its inactivation alter the global expression profiles in a very similar wa...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37961 | biostudies-arrayexpress
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37962 | biostudies-arrayexpress
ProteomicsOptimization of label-free nano LC-MS/MS analysis of the placental proteome
We optimized a protocol to analyze the placental proteome by means of label-free nano-LC-MS/MS mass spectrometry with regard to sample treatment, protein extraction, and protein digestion, in order to obtain a high protein concentration for identification of a specific protein signature according to...
ORGANISM(S): Homo sapiens (Human) 
2020-10-13 | PXD020438 | Pride
Placenta Lc-msms 
ProteomicsThe lipid transport Mla Pqi Chimeric system is essential for Brucella abortus survival in macrophages
Envelope integrity is essential for diderm bacteria. The envelope is composed of an inner membrane (IM) and an outer membrane (OM), which are separated by a periplasmic space. Several pathways have been recently identified that facilitate the transport of phospholipids between the two membranes in E...
ORGANISM(S): Brucella abortus 
2025-06-19 | PXD057244 | Pride
Lipid transport  outer membrane biogenesis  gram negative cell envelope  pqi  mla  envelope spanning  brucella 
ProteomicsEquine muscle-derived mesenchymal stem cells protect cartilage explants in osteoarthritis model: secretome characterization
Background: Osteoarthritis is a highly prevalent joint degenerative disease for which therapeutic treatments are limited or invasive. Cell therapy based on mesenchymal stem/stromal cells (MSCs) is therefore seen as a promising approach for this disease, in both human and horses. Objective: As the r...
ORGANISM(S): Equus caballus (Horse) 
2022-11-08 | PXD031924 | Pride
Stem cells  equine Secretome 
ProteomicsIGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in metastatic breast cancer
In the context of breast cancer metastasis study, we have shown in an in vitro model of cell migration that IGDQ-exposing (IsoLeu-Gly-Asp-Glutamine type I Fibronectin motif) monolayers (SAMs) on gold sustain the adhesion of MDA-MB-231 cells by triggering Focal Adhesion Kinase by activating integrins...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD024540 | Pride
Breast cancer  tnbc  cell migration  motogenic igdq motif  fibronectin type i  integrin alpha 5  integrin beta 3 
ProteomicsEndogenous TOM20 proximity labelling: a Swiss-knife for the study of mitochondrial proteins in human cells
The majority of mitochondrial proteins are encoded by the nuclear genome and must be imported into the mitochondria. There are two main paths for mitochondrial protein import: post-translational and co-translational import. Co-translational import couples the translation and the translocation of the...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD038821 | Pride
Mitochondria  co-translational import  bioid  protein identification  mass spectrometry 
ProteomicsData from “A biocodicological analysis of the medieval library and archive from Orval Abbey, Belgium.
The dataset contains the first-ever comprehensive biocodicological analysis of medieval library books and chapters using zooarchaeological mass spectrometry (ZooMS). Here, we analyze 68 codices and 59 charters (1490 samples in total) from one single monastic institution, namely the Cistercian abbey ...
ORGANISM(S): Bos taurus (Bovine) Capra hircus x Ovis aries 
2022-02-22 | PXD029196 | Pride
Charters Orval Codices Lc-msms 
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator [expression]
The L-Mediator is a general co-activator of RNA Polymerase II transcription and is formed by the reversible association of the S-Mediator and the kinase module harbouring Cdk8. We describe the Cdk11-Lcp1 complex and show that its inactivation alter the global expression profiles in a very similar wa...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37960 | biostudies-arrayexpress
ProteomicsUpregulation of the AcrAB2NodT efflux pump confers antibiotic resistance at the cost of collateral metal sensitivity
Bacterial resistance to antibiotics (AB) such as β-lactams, fluoroquinolones, and aminoglycosides often emerges through mutations that alter AB targets, reduce membrane permeability, or increase the activity of AB-modifying enzymes and efflux pumps. Yet the physiological costs associated with AB res...
ORGANISM(S): Caulobacter vibrioides 
2026-03-02 | PXD067190 | Pride
Antibiotics Heavy metals Metal sensitivity Stress response Caulobacter Efflux pumps Antibiotic resistance Copper 
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