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ProteomicsLoss of p14 reduces immunogenicity in melanoma by affecting the peptide surface density via non-canonical Wnt signaling
CDKN2A and its two gene products p14 and p16 are one of the most frequently negatively altered gene loci (either by loss or mutation) in advanced melanoma accompanied by decreased T cell infiltration in melanoma. In this study, we shed light on the connection of the reduction of the CDKN2A gene prod...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046891 | Pride
Hla Human immunopeptidome Differnetiation antigen Melanoma 
TranscriptomicsUsp22 depletion in E14 mouse ESCs
Mouse ESCs depleted of the epigenetic modifying enzyme Usp22 fail to differentiate properly. Ectopic expresison of Usp22 results in spontaneous differnetiation. In order to understand the transcriptional program underlying this biological defect, whole genome expression analysis was performed. E14 ...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-42934 | biostudies-arrayexpress
TranscriptomicsIdentification of bone morphogenetic protein (BMP)-7 as a key instructive factor for human epidermal Langerhans cell differentiation and proliferation
Langerhans dendritic cells represent abundantly occuring and evolutionary highly conserved DCs specifically located in the stratified epithelial tissues. LCs are unique among DC family members in that they express epithelial-type adhesion molecules, allowing them to form a tight three-dimensional ne...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-49085 | biostudies-arrayexpress
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