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TranscriptomicsAffymetrix SNP array data for Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of paediatric malignancies and one for which no effective therapy exists. A major contributor to the failure of therapeutic trials is the assumption that biologic properties of brainstem tumours in children are identical to cereb...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-18828 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
GenomicNext Generation Sequencing of Diffuse Intrinsic Pontine Glioma Samples

Diffuse intrinsic pontine glioma (DIPG) is an extremely rare (~350 cases/year) and universally fatal childhood brain cancer. Standard clinical strategies such as chemotherapy and radiotherapy show only transient improvement in patient condition and result in negligible change in survival, DIPG re...

phs001526 | dbGaP
TranscriptomicsIllumina Infinium 450K array data for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-50022 | biostudies-arrayexpress
TranscriptomicsIllumina HT-12 expression array data for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-50021 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP 6.0 array data for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-50024 | biostudies-arrayexpress
ProteomicsProteomic analysis of chemical and genetic EZH2 inhibition in diffuse intrinsic pontine glioma cell lines
Diffuse Intrinsic Pontine Glioma (DIPG) is a rare and highly aggressive pediatric tumor. The average survival time after diagnosis is less than one year. Currently, there are no effective treatments. Characteristic of DIPG is a mutation in histone H3 which leads to a substitution of Lysine 27 to Met...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD017525 | Pride
Ezh2 inhibition Quantitative proteome Gsk126 Diffuse intrinsic pontine glioma Ezh2 knock down 
TranscriptomicsIllumina Infinium HumanMethylation450 BeadChip profiling of paediatric high grade gliomas and diffuse intrinsic pontine gliomas
We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas and diffuse intrinsic pontine gliomas. The 450K methylation array is being used to separate brain tumour samples on the basis of their methylation profiles which represent the cell of...
ORGANISM(S): Homo sapiens 
2017-09-28 | E-MTAB-5528 | biostudies-arrayexpress
ProteomicsHuman diffuse intrinsic pontine glioma (DIPG) LC-MSMS
Diffuse intrinsic pontine glioma (DIPG), a lethal pediatric cancer driven by H3K27M oncohistones, exhibits aberrant epigenetic regulation and stem-like cell states. Here, we uncover an axis involving H3.3K27M oncohistones, CREB5/ID1, which sustains the stem-like state of DIPG cells, promoting malign...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD053094 | Pride
Human Dipg cell lines Ip-ms 
ProteomicsHuman diffuse intrinsic pontine glioma (DIPG) LC-MSMS
Diffuse intrinsic pontine glioma (DIPG), a lethal pediatric cancer driven by H3K27M oncohistones, exhibits aberrant epigenetic regulation and stem-like cell states. Here, we uncover an axis involving H3.3K27M oncohistones, CREB5/ID1, which sustains the stem-like state of DIPG cells, promoting malign...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD060271 | Pride
Human Dipg cell lines Ip-ms 
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