Sort   by:  
 Page size 
MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
TranscriptomicsExpression profiling of Jurkat cells infected with HIV-1 and treated with digoxin or DMSO
To determine changes of gene expression in human CD4+ T cells (Jurkat) infected with HIV-1 and treated with digoxin. Cells were infected (MOI 0.01) with a single cycle HIV-1 delta env expressing GFP and pseudotyoed with VSV-G in the presence of 400nM digoxin or DMSO. Cells were harvested 36 hours po...
ORGANISM(S): Homo sapiens 
2017-08-19 | E-MTAB-5982 | biostudies-arrayexpress
TranscriptomicsDigoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (Th17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes in humans. Genome-wide association studies in humans have linked genes involved in Th17 cell differe...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-27241 | biostudies-arrayexpress
ProteomicsDigoxin induces astrocyte activation into a human in vitro astrocyte model
In this study we have evaluated the effect of digoxin in human astrocytes. Our results have shown that non-cytotoxic concentration of digoxin is able to induce astrocytes activation, by affecting cytoskeleton proteins, increasing the expression of pro-inflammatory genes and altering energy metabolis...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029370 | Pride
Neurotoxicty Astrocytes Neuroinflammation Energy metabolism Astrogliosis Glycolysis 
GenomicsTranscriptome analysis of Group 3 and 4 medulloblastoma orthotopic xenograft mice with digoxin treatment
Transcriptome analysis of Group 3 and 4 medulloblastoma orthotopic xenograft mice with digoxin treatment
PRJNA475298 | ENA
GenomicsSingle-cell RNA-seq profiles of murine sarcoma tumors with vehicle and digoxin treatments
Single-cell RNA-seq profiles of murine sarcoma tumors with vehicle and digoxin treatments
PRJNA629842 | ENA
GenomicsDigoxin treatment is associated with thyroid cancer differentiation and radioactive iodide treatment response
Digoxin treatment is associated with thyroid cancer differentiation and radioactive iodide treatment response
PRJNA445240 | ENA
GenomicsTranscriptomic profiles of synchronized AC16 cells after a kinetic exposition to digoxin
Transcriptomic profiles of synchronized AC16 cells after a kinetic exposition to digoxin
PRJNA923011 | ENA
GenomicsThe gene microarray of digoxin on high-fat diet (HFD) induced changes in liver tissue
The gene microarray of digoxin on high-fat diet (HFD) induced changes in liver tissue
PRJNA428877 | ENA
GenomicsExpression profiling of Jurkat cells infected with HIV-1 and treated with digoxin or DMSO
Expression profiling of Jurkat cells infected with HIV-1 and treated with digoxin or DMSO
PRJEB22183 | ENA
Sort   by:  
 Page size