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MetabolomicsCardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy
Succinate dehydrogenase, which is known as mitochondrial complex II, has proven to be a fascinating machinery, attracting renewed and increased interest in its involvement in human diseases. Herein, we find that succinate dehydrogenase assembly factor 4 (SDHAF4) is downregulated in cardiac muscle in...
2022-08-12 | MTBLS4579 | MetaboLights
TranscriptomicsDeleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy
Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-82290 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart left ventricle from patients with idopathic dilated cardiomyopathy and normal controls
The mechanisms underlying the balancing of circulatory demands against changes in cellular homeostasis and cell death/survival signaling in heart muscle disease are still not fully understood. We employed the ABI high-density oligonucleotide microarrays containing 31,700 sixty-mer oligonucleotide pr...
ORGANISM(S): Homo sapiens 
2010-01-01 | E-TABM-480 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of CTGF inhibition in a transgenic mouse model of dilated cardiomyopathy
Cardiac structural changes associated with dilated cardiomyopathy (DCM) include cardiomyocyte hypertrophy and myocardial fibrosis. Connective Tissue Growth Factor (CTGF) has been associated with tissue remodeling and is highly expressed in failing hearts. To test if inhibition of CTGF would alter ...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-68857 | biostudies-arrayexpress
TranscriptomicsMolecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy: left ventricle DCM
We wanted to see whether the set of affected genes in ischemic cardiomyopathy (ICM) is the same or different as compared to dilated cardiomyopathy (DCM). To find this out, we placed the single DCM sample on the same microarray slide with the ICM samples. Analysis of microarray data with ICM samples ...
ORGANISM(S): Homo sapiens 
2010-06-17 | E-GEOD-17530 | biostudies-arrayexpress
ProteomicsInegrative Proteomic Analysis Reveals the Cytaskeleton Regulation and Mtophagy Diference Between ischemicCardiomyopathy and Dilated Cardiomyopathy
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary etiologies of end-stage heart failure. However, there remains a dearth of comprehensive understanding the global perspective and the dynamics of the proteome and phosphoproteome in ICM and DCM, which hinders the profo...
ORGANISM(S): Homo Sapiens 
PXD065145 |
MetabolomicsCore Functional Nodes and Sex-Specific Pathways in Human Ischemic and Dilated Cardiomyopathy
Not available
ORGANISM(S): Homo sapiens 
ST001364 | MetabolomicsWorkbench
TranscriptomicsDilated Cardiomyopathy in Dobermans and Boxers
This study attempts at investigating the changes in cardiac gene expression that occur in Dilated Cardiomyopathy (DCM). DCM in Dobermans and Boxers are the focus of this study. Control heart tissue as well as Pacing tissue used is from mongrel dogs. Keywords: control vs pacing vs disease; strain sp...
ORGANISM(S): Canis lupus familiaris 
2008-05-08 | E-GEOD-11015 | biostudies-arrayexpress
TranscriptomicsLoss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure.
RATIONALE: Heart failure is a deadly and devastating disease that places immense costs on an aging society. To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function. OBJECTIVE: microRNAs are impor...
ORGANISM(S): Mus musculus 
2011-10-11 | E-GEOD-32881 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of a mouse model of dilated cardiomyopathy
Analysis of the effects of aging on the development of dilated cardiomyopathy by characterizing both changes in ejection fraction (EF) and gene expression profile in 3 groups of male mice: Control (Cont or WT, n=11) and transgenic (Tg or KO) mice with either high EF (KO-H or Tg-H, n=7) or low EF (K...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-16909 | biostudies-arrayexpress
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