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ProteomicsInvestigation of the host response of naïve Atlantic salmon gill to repeat inoculation with Paramoeba perurans
In aquaculture, recurrence rates of Amoebic Gill Disease (AGD), caused by the ectoparasite Paramoeba perurans (P. perurans) are high and no prophylactic strategies exist for disease prevention. In this study, Atlantic salmon (Salmo salar) were initially inoculated with P. perurans and following the ...
ORGANISM(S): Salmo salar (Atlantic salmon) 
2021-05-21 | PXD024096 | Pride
Salmon Gill Proteomics 
ProteomicsInvestigation of the host response of naïve Atlantic salmon (Salmo salar) inoculated with Paramoeba perurans prior to the onset of clinical symptoms
Amoebic Gill Disease (AGD), caused by the ectoparasite Paramoeba perurans (P. perurans) is characterised by hyperplasia of the gill epithelium and lamellar fusion and has become recognised as one of the most significant health threats in salmon farming . In this study, the gill and serum proteomes o...
ORGANISM(S): Salmo salar (Atlantic salmon) 
2021-04-16 | PXD022101 | Pride
Serum proteome Atlantic salmon Gel-free proteomics Amoebic gill disease Gill proteome 
ProteomicsHuman skeletal muscle proteome responses to weight loss induced by bariatric surgery or low-calorie diet
Obesity has been linked to lower mitochondrial metabolism in skeletal muscle. Weight loss yields many metabolic advantages, yet the effect of bariatric surgery versus caloric restriction on skeletal muscle mitochondrial metabolism and proteome remains to be elucidated.
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD061410 | Pride
Caloric restriction Low-calorie diet Skeletal muscle Weight loss Bariatric surgery 
ProteomicsBCAS0292 is involved in the adaptation of Burkholderia cenocepacia and shows characteristics of a DNA mimic protein AFFINITY PURIFICATION
Adaptation of opportunistic pathogens to their host environment requires reprogramming of a vast array of genes to facilitate host survival in the host. Burkholderia cenocepacia, a Gram-negative bacterium with a large genome of ~ 8Mb in size that colonizes environmental niches, is exquisitely adapta...
ORGANISM(S): Burkholderia cenocepacia Bacteria 
2022-01-11 | PXD030041 | Pride
Dna-protein interactions Burkholderia Host-pathogen interactions  respiratory infections  bacterial adaptation 
ProteomicsPhysiological shear stress markedly alters the proteomic response to hypoxia in human pulmonary microvascular endothelial cells
Physiological shear stress, produced by blood flow, homeostatically regulates the phenotype of pulmonary endothelial cells exerting anti-inflammatory and anti-thrombotic actions and maintaining normal barrier function. In the pulmonary circulation hypoxia, due to high altitude or diseases such as CO...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036260 | Pride
Shear stress Copd Human pulmonary microvascular endothelial cells Hypoxia 
ProteomicsComprehensive proteomics analysis of polyhydroxyalkanoate (PHA) biology in Pseudomonas putida KT2440: the outer membrane lipoprotein OprL is a newly identified phasin Dataset 3
Pseudomonas putida KT2440 is an important bioplastic-producing industrial microorganism capable of synthesizing the polymeric carbon-rich storage material, polyhydroxyalkanoate (PHA). PHA is sequestered in discrete PHA granules, or carbonosomes, and accumulates under conditions of stress, for examp...
ORGANISM(S): Pseudomonas putida KT2440 
2024-06-16 | PXD045993 | Pride
Proteomics Pseudomonas putida Bioplastics 
ProteomicsInhibition of pro-inflammatory signalling in human primary macrophages by enhancing Arginase-2 via target site blockers
A favourable immunotherapeutic strategy in the treatment of chronic inflammatory disease, is to dampen the pro-inflammatory macrophage response and upregulate the anti-inflammatory macrophage response. Previous studies have shown that Arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035018 | Pride
Macrophage Proteomics Multiple sclerosis Inflammation 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 2B; S. capsularis Y-17639 tRNA-Leu(CAG) deletion Sporulation condition
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044731 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 5A; S. capsularis CBS5638 Vegetative growth
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044763 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation 5B; S. capsularis CBS5638 Sporulation
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044772 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
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