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ProteomicsNovel in vivo models of autosomal optic atrophy show conserved pathological changes in mitochondrial structure and function ZEBRAFISH DATASET
Autosomal optic atrophy (AOA) is a form of hereditary optic neuropathy characterized by the irreversible and progressive degermation of the retinal ganglion cells. Most cases of AOA are associated with a single dominant mutation in OPA1, which encodes a protein required for fusion of the inner mitoc...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-05-07 | PXD059584 | Pride
Zebrafish  drosophila  mitochondria  optic atrophy  visual impairment. project description: 
ProteomicsThe role of HIF1 in enhancing radio resistance of mouse MSCs
Mesenchymal stromal cells (MSCs) are multipotent progenitors supporting bone marrow hematopoiesis. MSC have an efficient DNA damage response (DDR) and are consequently reatively radio-resistant cells. Therefore, MSCs are key to hematopoietic reconstitution following total body irradiation (TBI) and ...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-16 | PXD006701 | Pride
Label-free proteomics Hypoxia Mesenchymal stromal cells Ionizing radiation Dna damage response 
ProteomicsThermal Proteome Analysis of nutrient stress in Cupriavidus necator expression dataset
The facultative chemolithoautotroph Cupriavidus necator is capable of heterotrophic growth on diverse carbon sources or of autotrophic growth using CO2 fixation with H2 as an energy source. Under stress conditions, it is capable of producing biodegradable polyesters (polyhydroxyalkanoates, PHAs) as ...
ORGANISM(S): Bacteria Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 
2025-11-10 | PXD062592 | Pride
Expression proteomics Thermal proteomics 
ProteomicsBCAS0292 is involved in the adaptation of Burkholderia cenocepacia and shows characteristics of a DNA mimic protein WHOLE PROTEOME
Adaptation of opportunistic pathogens to their host environment requires reprogramming of a vast array of genes to facilitate host survival in the host. Burkholderia cenocepacia, a Gram-negative bacterium with a large genome of ~ 8Mb in size that colonizes environmental niches, is exquisitely adapta...
ORGANISM(S): Burkholderia cenocepacia Bacteria 
2022-01-11 | PXD030042 | Pride
Dna-protein interactions Burkholderia Host-pathogen interactions  respiratory infections  bacterial adaptation 
ProteomicsLysR type transcriptional regulator TtdR regulates both ethylene glycol and polyhydroxyalkanoate (PHA) metabolism in Pseudomonas umsongensis GO16 Dataset 1
Proteomic analysis was employed to elucidate the regulatory role of TtdR, a LysR-type transcriptional regulator located upstream of the glyoxylate carboligase gene (gcl) in Pseudomonas umsongensis GO16. While the wildtype strain can utilize ethylene glycol (EG) as a sole carbon and energy source, th...
ORGANISM(S): Pseudomonas umsongensis 
2026-09-07 | PXD075284 | Pride
Pseudomonas umsongensis go16  terephthalic acid  glucose  lysr-type transcriptional regulator  polyhydroxyalkanoates 
ProteomicsLysR type transcriptional regulator TtdR regulates both ethylene glycol and polyhydroxyalkanoate (PHA) metabolism in Pseudomonas umsongensis GO16 Dataset 2
Proteomic analysis was employed to elucidate the regulatory role of TtdR, a LysR-type transcriptional regulator located upstream of the glyoxylate carboligase gene (gcl) in Pseudomonas umsongensis GO16. While the wildtype strain can utilize ethylene glycol (EG) as a sole carbon and energy source, th...
ORGANISM(S): Pseudomonas umsongensis 
2026-09-07 | PXD075327 | Pride
Pseudomonas umsongensis go16  terephthalic acid  glucose  lysr-type transcriptional regulator  polyhydroxyalkanoates 
ProteomicsSmall extracellular vesicles secreted by cisplatin-resistant neuroblastoma cells increase lactate secretion and alter metabolic pathways in primary human umbilical vein endothelial cells (HUVECs)
Background: Chemoresistance, particularly to cisplatin, remains a significant challenge in treating high-risk neuroblastoma, resulting in a mere 20% five-year overall survival rate. Tumour-derived small extracellular vesicles (sEVs) have been implicated in cancer progression by promoting angiogenesi...
ORGANISM(S): Homo sapiens (Human) 
2025-11-04 | PXD069251 | Pride
Extracellular vesicles 
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