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ProteomicsIdentification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveal Actions Independent of Keap1 Activation
The fumarate ester dimethyl fumarate (DMF) has been introduced recently for the treatment of relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition resulting in neuronal demyelination and axonal loss. The complete mechanism of DMF action is unknown, but involves the depletio...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-02-19 | PXD008314 | Pride
Astrocytes Neurons Chemical modification Dimethyl fumarate 
ProteomicsDimethyl fumarate targets in macrophages
To understand the molecular mechanism underlying DMF’s inhibition of NLRP3 inflammasome in macrophage, we conducted chemoproteomics to identify the specific protein targets of DMF. We used MMFyne, a previously reported clickable DMF analogue to label and help identify potential DMF target proteins i...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD063777 | Pride
Macrophage Dimethyl fumarate 
ProteomicsFumarate effect on the Escherichia coli proteome at aerobic and anaerobic growth conditions
The changes in protein composition of E. coli were studied in a global proteomic approach for aerobic growth without or with fumarate as carbon source (glycerol + O2, fumarate + O2, respectively) and anaerobic growth without or with fumarate as carbon source (glycerol + DMSO, glycerol + DMSO + fumar...
ORGANISM(S): Escherichia coli 
2019-11-20 | PXD011760 | Pride
Escherichia coli  fumarate metabolism Aerobic/anaerobic growth  c4-dicarboxylates Lc-udmse 
ProteomicsChemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells
Primary human and mouse T cells were treated with the multiple sclerosis drug dimethyl fumarate (DMF) or its in vivo metabolite monomethyl fumarate (MMF). Cysteines sensitive to DMF or MMF were identified using iodoacetamide alkyne enrichment.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-08-31 | MSV000080111 | MassIVE
GenomicsDifferential neuroprotective and anti-inflammatory effects of dimethyl fumarate, monomethyl fumarate and cannabidiol in neurons and microglia
Differential neuroprotective and anti-inflammatory effects of dimethyl fumarate, monomethyl fumarate and cannabidiol in neurons and microglia
PRJNA1146415 | ENA
ProteomicsFumarate hydratase suppresses glioblastoma progression via a TRIM17-RRN3 proteostatic axis
Emerging evidence indicates that metabolic reprogramming plays a pivotal role in glioblastoma (GBM) progression. Here, we report that the expression of fumarate hydratase (FH) is significantly reduced in GBM patient samples. FH overexpression suppresses the viability, migration, and invasion of GBM ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067085 | Pride
Human Succination U87 Gbm Lc-ms/ms 
GenomicsDifferential neuroprotective and anti-inflammatory effects of dimethyl fumarate, monomethyl fumarate and cannabidiol in neurons and microglia [Mouse]
Differential neuroprotective and anti-inflammatory effects of dimethyl fumarate, monomethyl fumarate and cannabidiol in neurons and microglia [Mouse]
PRJNA1148203 | ENA
GenomicsGenomic H3K36me2 enrichment profile for Vehicle or dimethyl fumarate-treated mouse bone marrow-derived neutrophil
Genomic H3K36me2 enrichment profile for Vehicle or dimethyl fumarate-treated mouse bone marrow-derived neutrophil
PRJNA1473268 | ENA
GenomicsDimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL
Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL
PRJNA689774 | ENA
GenomicsDimethyl Fumarate (DMFu) as an anti-angiogenic agent in VEGF-treated human microvascular retinal endothelial cells (HRECs).
Dimethyl Fumarate (DMFu) as an anti-angiogenic agent in VEGF-treated human microvascular retinal endothelial cells (HRECs).
PRJNA1204363 | ENA
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