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ProteomicsSuccination of Tubulin and VDAC2 in the Mouse Brainstem
Elevated fumarate concentrations resulting from inhibition of the Krebs cycle lead to increases in protein succination, an irreversible post-translational modification that occurs when fumarate reacts with cysteine residues to generate S-(2-succino)cysteine (2SC). Metabolic events that reduce NADH r...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-16 | PXD002991 | Pride
Succination tubulin vdac2 
ProteomicsSuccination analysis of JAK1 and IKK2 using targeted MS/MS analysis
Using Affinity Purification in tandem to targeted LC-MS/MS analysis, we identified possible succination sites of JAK1 and IKK2 proteins follwoing DMF treatement. We looked for the specific 2-Dimethylsuccinyl modifications of Cysteins residues.
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD024441 | Pride
Cysteins succination Affinity mass spectrometry Jak Dmf Ikkb 
ProteomicsFumarate hydratase suppresses glioblastoma progression via a TRIM17-RRN3 proteostatic axis
Emerging evidence indicates that metabolic reprogramming plays a pivotal role in glioblastoma (GBM) progression. Here, we report that the expression of fumarate hydratase (FH) is significantly reduced in GBM patient samples. FH overexpression suppresses the viability, migration, and invasion of GBM ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067085 | Pride
Human Succination U87 Gbm Lc-ms/ms 
UnknownIdentification of protein succination as a novel modification of tubulin.
Not available
S-EPMC4324573 | biostudies-literature
UnknownInhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
Not available
S-EPMC3617368 | biostudies-literature
UnknownSuccination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes.
Not available
S-EPMC5655420 | biostudies-literature
UnknownSuccination inactivates gasdermin D and blocks pyroptosis.
Not available
S-EPMC8744141 | biostudies-literature
UnknownSuccination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome.
Not available
S-EPMC4739666 | biostudies-literature
UnknownFumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
Not available
S-EPMC5357164 | biostudies-literature
ProteomicsProteins modified by succination
Fumarate accumulation during renal fibrosis may be involved in renal inflammation by conferring succination to certain proteins to influence intracellular signaling. We applied a Desthiobiotin-Iodoacetamide (DBIA) probe as a competitive probe for covalently labelling fumarate and combined with a liq...
ORGANISM(S): Mus Musculus 
PXD063006 |
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