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TranscriptomicsTranscription profiling of mouse models with liver-specific deletion or global hypomorphic expression of the NADPH-cytochrome P450 reductase gene to study molecular mechanisms for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
NADPH-cytochrome P450 reductase (CPR) is important for the functions of many enzymes, such as microsomal cytochrome P450 (P450) monooxygenases and heme oxygenases. Two mouse models with deficient CPR expression in adults were recently generated in this laboratory: liver-Cpr-null (with liver-specific...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2362 | biostudies-arrayexpress
ProteomicsStreptamidine, streptapyrimidone and spyrimidone production in Streptomyces albidoflavus J1074 and S. coelicolor M1146-pCAPSalbC
Data used to evaluate temporal progression of streptamidine, streptapyrimidone, spyrimidone and glycosylated spyrimidone production in Streptomyces albidoflavus J1074 and the heterologous host Streptomyces coelicolor M1146 expressing the streptamidine (ami) cluster. LC-MS/MS data used to characteris...
ORGANISM(S): Streptomyces Albidoflavus J1074 Streptomyces Coelicolor M1146 
2024-04-18 | MSV000094563 | MassIVE
GenomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33653 | biostudies-arrayexpress
TranscriptomicsCopy number variation analysis of hepatic metastases from uveal melanoma
Metastatic uveal melanoma (MUM) is chemoresistant and usually fatal within one year of diagnosis. There is an urgent need to better understand disease pathogenesis, in order to determine key drivers of the metastatic process that could be effectively targeted by therapy. Gene copy number variations ...
ORGANISM(S): Homo sapiens 
2016-05-18 | E-GEOD-69614 | biostudies-arrayexpress
UnknownNeutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
Not available
S-EPMC7332453 | biostudies-literature
ProteomicsFly Stress - Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster
Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. While ageing and fasting alter many redox processes, the role of cysteine residues is uncertain. To address this we used a redox proteomic technique, Oxidative Isotope Coded Affini...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-10-24 | PXD002195 | Pride
Drosophila Starvation Ros Aging 
TranscriptomicsGene expression analysis of peripheral whole blood RNA following ischemic stroke
The purpose of this project was to elucidate gene expression in the peripheral whole blood of acute ischemic stroke patients to identify a panel of genes for the diagnosis of acute ischemic stroke. Peripheral blood samples were collected in Paxgene Blood RNA tubes from stroke patients who were >18 y...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-16561 | biostudies-arrayexpress
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
TranscriptomicsDirect Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (microarray)
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds direct...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-33659 | biostudies-arrayexpress
GenomicsAssociation studies using the Metabochip array - Samples analysed by the WTCCC (1958 British Birth Cohort (58BC), Hypertension cohort (HT), Type 2 Diabetes Cohort (T2D) and Coronary Artery Disease (CAD) cohort)
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effectiv...
EGAS00000000115 | EGA
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