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ProteomicsJMJD2 regulates enhancer-promoter interactions via biocondensate formation
Enhancer-promoter (E-P) interactions regulate transcription for cell fate determination. However, the regulatory mechanisms of E-P interactions remain elusive. Here, a chromatin interaction-based proteomics approach, LoopID, was developed to profile the proteins at certain E-P anchors, which were te...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD069064 | Pride
Enhancer-promoter interactions Proximity ligation Loopid Biocondensates Proteome 
GenomicsTex10 Coordinates Epigenetic Control of Super-Enhancer Activity for Pluripotency and Reprogramming [ChIP-Seq]
Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage specific transcription factors driving expression of genes that define cell identity. In embryonic stem cells (ESCs), SEs are highly enriched for Oct4, Sox2, and Nanog in the enhanceosome a...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-66735 | biostudies-arrayexpress
TranscriptomicsTex10 Coordinates Epigenetic Control of Super-Enhancer Activity for Pluripotency and Reprogramming [RNA-Seq]
Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage specific transcription factors driving expression of genes that define cell identity. In embryonic stem cells (ESCs), SEs are highly enriched for Oct4, Sox2, and Nanog in the enhanceosome a...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-66734 | biostudies-arrayexpress
ProteomicsThe response mechanism of Cucurbita ficifolia under the FoC stress and the Identification of NBS type disease -resistance genes
For the first time, this study reveal the response of C. ficifolia leaf to FOC infection at the transcriptome and proteome levels, uncovered that FOC infection activates plant hormone signaling, and transcription factors while suppressing wax biosynthetic process and photosynthesis. The results prov...
ORGANISM(S): Cucurbita Ficifolia 
PXD028075 |
ProteomicsProteomics reveals the significance of vacuole Pi transporter in the adaptability of Brassica napus to Pi deprivation
A proteomic analysis was performed to estimate the role of BnPHT5;1a in Pi fluctuation. Results showed that Pi deprivation disturbed the physiological processes involved in carbohydrate metabolism, response to stimulus and stress in B. napus, while disruption of BnPHT5;1a genes exacerbated these pro...
ORGANISM(S): Brassica Napus 
2023-11-16 | PXD047074 |
ProteomicsNuclear polysaccharides maintain H3K9me3-heterochromatin and genomic stability
Polysaccharides are traditionally confined to the cell surface and extracellular space, whereas their nuclear roles remain unclear. Here, we show that N-glycans are present in the nucleus and modify inner nuclear membrane (INM) proteins across multiple cell types. Disruption of INM protein N-glycosy...
ORGANISM(S): Mus Musculus 
2025-12-30 | PXD072505 |
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