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Methanothermobacter thermautotrophicus is a model thermophilic hydrogenotrophic methanogen. The life and survival of M. thermautotrophicus is highly influenced by the availability of nutrients and temperature. To learn about adaptation mechanisms evolved by the archaea to cope with drastic temperatu...
ORGANISM(S): Methanobacterium 
2018-10-02 | PXD006685 | Pride
The synthetic lethal association between BRCA deficiency and poly (ADP-ribose) polymerase (PARP) inhibition supports PARP inhibitor (PARPi) clinical efficacy in BRCA-mutated tumors. PARPis also demonstrate activity in non-BRCA mutated tumors presumably through induction of PARP1-DNA trapping. Despit...
ORGANISM(S): Homo sapiens (Human) 
2022-07-08 | PXD033530 | Pride
Plants respond to environmental stresses by altering transcription of genes involved in the response. The chromatin modifier ATX1 influences gene expression and factors that modulate ATX1 activity would affect indirectly the expression of ATX1-regulated genes. Here, we demonstrate that dehydration ...
ORGANISM(S): Arabidopsis thaliana 
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