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ProteomicsMolecular signatures of membrane protein complexes underlying muscular dystrophy
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating ...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-12 | PXD002846 | Pride
Mouse Directed ms (dms) Skeletal muscle Membrane protein complexes 
ProteomicsQuantitative cardiac phosphoproteomics profiling during ischemic/reperfusion in an immature swine model
Ischemia/Reperfusion (I/R) results in altered metabolic and molecular responses. Phosphorylation, a posttranslational modification, is one of the most noted regulatory mechanisms and differential phosphorylation affects numerous regulatory and signaling mechanisms. To further understand the phosphop...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2017-05-02 | PXD006066 | Pride
Proteomics Phosphopeptide quantitation Itraq 
ProteomicsMolecular signatures of membrane protein complexes underlying muscular dystrophy
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-22 | PXD004020 | Pride
Mouse Glycoproteomics Sucrose fractionation Directed ms Skeletal muscle 
UnknownMolecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria.
Not available
S-EPMC5651017 | biostudies-literature
ProteomicsAndrogen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells
Aberrant androgen receptor (AR)-mediated transcription is a critical driver in progression of human prostate cancer. It's known that different doses of androgens can elicit differential transcriptional and proliferative responses in prostate-tumor cells. Here, we set out to examine the androgenic re...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD002913 | Pride
Androgen Human prostate cancer cells Lectin affinity purification 
ProteomicsDiscovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription
Aberrant activation of androgen receptor (AR)-dependent transcriptional programs is a hallmark of human prostate cancers. At the molecular level, ligand-mediated AR activation is coordinated through spatial and temporal protein-protein interactions (PPIs) involving AR-interacting proteins, which we ...
ORGANISM(S): Homo sapiens (Human) 
2016-07-20 | PXD002861 | Pride
Androgen Transcription Intracellular trafficking Prostate cancer Protein trafficking Mass spectrometry-based proteomics Androgen receptor Golgi membrane 
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