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UnknownBRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
Not available
S-EPMC4356711 | biostudies-literature
TranscriptomicsSingle cell derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
Single cell derived clones were extracted from four glioblastoma tumors using fluorescence activated cell sorting with CD15 and CD133 markers. Unsorted bulk tumors were also derived. Gene expression analysis of clones of tumor GBM-482 involved comparison between TMZ resistant (n=5) and sensitive (n=...
ORGANISM(S): Homo sapiens 
2015-01-03 | E-MTAB-2693 | biostudies-arrayexpress
UnknownTelomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells.
Not available
S-EPMC4286630 | biostudies-literature
UnknownSurvival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.
Not available
S-EPMC6508980 | biostudies-literature
TranscriptomicsGenotype profiling of primitive neuroectodermal tumours (250K_Nsp_SNP and 250K_Sty_SNP)
Primitive neuro-ectodermal tumours (PNET) of the supratentorial region are rare, highly malignant embryonal brain tumours affecting young children. Although supratentorial PNET (sPNET) are histologically similar to infratentorial PNET/medulloblastoma, sPNET have more aggressive clinical phenotypes, ...
ORGANISM(S): Homo sapiens 
2009-12-21 | E-GEOD-14087 | biostudies-arrayexpress
UnknownATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.
Not available
S-EPMC4184920 | biostudies-literature
TranscriptomicsGenotype profiling of a primitive neuroectodermal tumour identifies a non-constitutive chr19q13.41 amplicon
Primitive neuro-ectodermal tumours (PNET) of the supratentorial region are rare, highly malignant embryonal brain tumours affecting young children. Although supratentorial PNET (sPNET) are histologically similar to infratentorial PNET/medulloblastoma, sPNET have more aggressive clinical phenotypes, ...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14248 | biostudies-arrayexpress
UnknownPervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.
Not available
S-EPMC6521975 | biostudies-literature
UnknownHigh-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.
Not available
S-EPMC6673710 | biostudies-literature
ProteomicsDisruption of splicing, proliferation and stemness via PRMT5 inhibition as a therapeutic strategy for GBM
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein Arginine Methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogonal-acting inhibitors of PRMT5 (GSK591 or LLY-283), ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-03 | PXD021635 | Pride
Cancer Proteomics Glioblastoma Prmt5 inhibition 
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