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ProteomicsDisabled-2 interacting proteins in U46619-stimulated human platelet activation
The interacting proteins of Disabled-2 (Dab2) and their functional consequences in U46619-stimulated human platelets were investigated.
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD048490 | Pride
U46619 stimulation Disabled-2 Human platelet Lc-ms/ms 
GenomicsThe Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages
The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages
PRJNA640048 | ENA
TranscriptomicsTranscriptome profiling reveals novel Disabled-2-associated downstream effectors in mouse embryonic stem cells (ESC)
Disabled-2 (DAB2) is up-regulated when ESC were cocultured with OP9 stromal cells for mesodermal colony formation. Expression of DAB2 short hairpin small interfering RNA (shDAB2) altered ESC cell-cell adhesion that subsequently affected colony formation and mesoderm differentiation competence. To fu...
ORGANISM(S): Mus musculus 
2009-08-12 | GSE17592 | GEO
TranscriptomicsThe Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages
Tumor-associated macrophages (TAMs) are regulators of extracellular matrix (ECM) remodeling and metastatic progression, the main cause of cancer-associated death. We found that disabled 2 mitogen-responsive phosphoprotein (DAB2) is highly expressed in tumor-infiltrating TAMs and its genetic ablation...
ORGANISM(S): Mus musculus 
2020-07-13 | GSE152674 | GEO
UnknownDisabled-2 downregulation promotes epithelial-to-mesenchymal transition.
Not available
S-EPMC2994233 | biostudies-literature
TranscriptomicsTranscription profiling of mouse embryonic stem cells reveals novel Disabled-2-associated downstream effectors
Disabled-2 (DAB2) is up-regulated when ESC were cocultured with OP9 stromal cells for mesodermal colony formation. Expression of DAB2 short hairpin small interfering RNA (shDAB2) altered ESC cell-cell adhesion that subsequently affected colony formation and mesoderm differentiation competence. To fu...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-17592 | biostudies-arrayexpress
UnknownCathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.
Not available
S-EPMC5937135 | biostudies-literature
UnknownSulfatides partition disabled-2 in response to platelet activation.
Not available
S-EPMC2778132 | biostudies-literature
TranscriptomicsDisabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization and signaling
Toll-like receptor 4 (TLR4) plays a pivotal role in the host response to lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria. Here we elucidated whether the endocytic adaptor protein Disabled-2 (Dab2) that is abundantly expressed in the macrophages plays a role in LPS-sti...
ORGANISM(S): Mus musculus 
2017-02-09 | GSE81088 | GEO
UnknownHuman Disabled-2 regulates thromboxane A2 signaling for efficient hemostasis in thrombocytopenia.
Not available
S-EPMC11561248 | biostudies-literature
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