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ProteomicsIncreased cholesterol biosynthesis identified as a key feature and a therapeutic target of cancer stem cells as revealed by proteomic comparison of clinical breast cancer tissue and corresponding patient-derived xenografts and mammospheres
Cancer stem cells (CSCs) comprise a small subpopulation of undifferentiated cancer cells with the ability to self-renew and give rise to the heterogeneous cancer cell lineages that form tumorous masses. Thus, tumor eradication may be greatly improved by specifically targeting CSCs, as they exhibit r...
ORGANISM(S): Homo sapiens (Human) 
2019-07-02 | PXD011222 | Pride
Ffpe tissue Breast cancer proteomics 
ProteomicsHuman,squamous cell lung cancer,LC-MS/MS
We compared the proteome of primary SqCLC tumor tissue between patients with ER (< 10 months) vs. LR (> 30 months) following surgery. iTRAQ-based quantitative 2D LC-MS/MS proteomics were performed on 20 SqCLC tumor samples (10 ER, 10 LR) using a matched pair design in which each ER tumor sample was ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD009383 | Pride
Human Lc-ms/ms Squamous cell lung cancer 
ProteomicsBreast Cancer
Endocrine resistance in breast cancer is a major clinical problem with poorly understood mechanisms. Mass spectrometry-based proteomics of a clinically-relevant tamoxifen-resistant cell line model identified increased levels of minichromosome maintenance proteins (MCM), including MCM3, as central in...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD001087 | Pride
Ndrg1 Tamoxifen resistance Estrogen receptor-positive breast cancer Cell cycle Minichromosome maintenance proteins (mcm) Dna replication 
ProteomicsMetastasis-related Intracellular Proteins in Human Breast Cancer Cells
We have used a unique metastasis model system in combination with quantitative, comparative proteomics to identify novel markers associated with the ability of cancer cells to colonize and form metastasis, and subsequently analyzed the clinical relevance of these proteins using breast cancer biopsie...
ORGANISM(S): Homo sapiens (Human) 
2015-09-14 | PXD001391 | Pride
Human Breast cancer Silac Esi-qtof Metastasis 
TranscriptomicsValidation of a laboratory assay for prediction of relapse in stage I non-small cell lung cancer (NSCLC) using miRNA profiling of formalin-fixed paraffin-embedded (FFPE) tissue specimens.
Technical validation of miRNA assay for prediction of relapse in NSCLC.
ORGANISM(S): Homo sapiens 
2011-10-28 | E-MTAB-618 | biostudies-arrayexpress
GenomicsIntegrative Analyses of Gene Expression and DNA Methylation Profiles in a Breast Cancer Cell Line Model of Tamoxifen-Resistance Indicate a Crucial Role of Cells with Stem-like Properties
Purpose: Development of resistance to tamoxifen is an important clinical issue in the treatment of patients with breast cancer. Tamoxifen resistance may be the result of the acquisition of epigenetic regulation such as DNA methylation within breast cancer cells resulting in changed mRNA expression o...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-40665 | biostudies-arrayexpress
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