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ProteomicsModulation of the ATM / autophagy pathway tips the balance between senescence and apoptosis in response to a quadruplex ligand
G-quadruplex ligands (G4L) exert their anti-proliferative effect through telomere-dependent and -independent mechanisms, but the inter-relationship between autophagy, cell growth arrest and cell death induced by these ligands remains largely unexplored. 20A is a 2,4,6-triarylpyridine derivative that...
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD009430 | Pride
G4  quadruplex ligand  autophagy  senescence  apoptosis  triarylpyridine  antiproliferative agents  label-free quantitative proteome analysis. 
ProteomicsCAMKK and CRAC channel regulate autophagy, differentiation and apoptosis in acute promylocytic leukemia cells treated by ATRA
ATRA is an active metabolite of vitamin A that is frequently used for the treatment of acute promyelocytic leukemia (APL) patients. Despite the success of this treatment, some APL patients are refractory or relapse. This emphasis the need for new therapeutic strategies aiming to improve the anti-ca...
ORGANISM(S): Homo sapiens (Human) 
2021-11-24 | PXD026904 | Pride
Calcium signaling Autophagy Differentiation Acute promyelocytic leukemai quantitative proteome Cell death 
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