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ProteomicsDLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling
Using stable cell lines, we found that succinylation levels were highly dependent on DLST. Furthermore, PPGL-causing DLST mutations, predicted to alter DLST homo-oligomeric complex structure, caused a significant remodeling of the cellular succinylome. Succinylation is thought to cause major chemica...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD036782 | Pride
Dlst  succinylation  pheochromocytoma  paraganglioma 
GenomicsGene expression analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation
Gene expression analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation
PRJNA867591 | ENA
GenomicsEpigenome analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation [methylation array]
Epigenome analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation [methylation array]
PRJNA867592 | ENA
GenomicsGene expression analysis of pheochromocytoma samples carrying co-occurrent mutations in NF1 and DLST.
Gene expression analysis of pheochromocytoma samples carrying co-occurrent mutations in NF1 and DLST.
PRJNA897908 | ENA
TranscriptomicsGene expression analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation
We performed gene expression profiling analysis using data obtained from RNA-seq of a paraganglioma sample carrying the DLST-p.Y422C mutation. The main goal of this project was to find specific gene expression profiles associated to the presence of mutations in the DLST gene of pheochromocytomas/par...
ORGANISM(S): Homo sapiens 
2023-05-05 | GSE210808 | GEO
UnknownThe TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.
Not available
S-EPMC4889531 | biostudies-literature
UnknownRecurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas.
Not available
S-EPMC6451733 | biostudies-literature
Methylation profilingEpigenome analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation [methylation array]
Genome wide DNA methylation profiling of a paraganglioma sample carrying the DLST-p.Y422C mutation. The Illumina Infinium EPIC Human DNA methylation Beadchip v1.2 was used to obtain a DNA methylation profile across approximately 850,000 CpGs. The main goal of this project was to find specific methyl...
ORGANISM(S): Homo sapiens 
2023-05-05 | GSE210809 | GEO
UnknownDLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer.
Not available
S-EPMC8595664 | biostudies-literature
UnknownEvolutionary trajectories of beta-lactamase NDM and DLST cluster in Pseudomonas aeruginosa: finding the putative ancestor.
Not available
S-EPMC11141312 | biostudies-literature
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