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TranscriptomicsGenome-wide studies of histone Me2 SWIRM and polyamine oxidase domain homologues of mammalian LSD1
In order to gain a more global view of the activity of histone demethylases we report here studies of the two fission yeast SWIRM and polyamine oxidase domain homologues of mammalian LSD1. Consistent with previous work (Nicolas et al., 2006) we find that the two S. pombe proteins, which we name Swm...
ORGANISM(S): Schizosaccharomyces pombe 
2010-05-27 | E-GEOD-6224 | biostudies-arrayexpress
TranscriptomicsThe S. cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2
Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approac...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-7627 | biostudies-arrayexpress
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [GSKJ4_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we chemically inhibited the H3K27me3 demethylase JMJD3 using the GSKJ4 inhibitor and assayed for genome-wide changes in H3K27me3 and JMJD3 enri...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56691 | biostudies-arrayexpress
GenomicsGlioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation
Tumor-initiating cells are a subpopulation of cells that have self-renewal capacity to regenerate a tumor. Here, we identify stem cell-like chromatin features in human glioblastoma initiating cells (GICs) and link them to a loss of the repressive histone H3 lysine 9 trimethylation (H3K9me3) mark. In...
EGAS00001003750 | EGA
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [short_hairpins_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we abrogated the expression of JMJD3 (KDM6B) and UTX (KDM6A) H3K27me3 demethylases in human T-ALL lines and assayed for genome-wide expression ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56689 | biostudies-arrayexpress
GenomicsInterplay Between Active Chromatin Marks and RNA-directed DNA Methylation in Arabidopsis thaliana
DNA methylation is an epigenetic mark that is associated with transcriptional repression of transposable elements and protein coding genes. Conversely, transcriptionally active regulatory regions are strongly correlated with histone 3 lysine 4 di- and trimethylation (H3K4m2/3). We previously showed ...
ORGANISM(S): Arabidopsis thaliana 
2013-11-01 | E-GEOD-49090 | biostudies-arrayexpress
TranscriptomicsIdentification of genes modulated by JIB-04 in lung cancer cells
JIB-04 is an inhibitor of Jumonji histone demethylases identified through a cell based screen that measures the reactivation of an epigenetically silenced transgene. The active JIB-04 E-isomer shows selectivity for cancer vs. normal cells affecting both transcriptional patterns and cell viability in...
ORGANISM(S): Homo sapiens 
2013-07-08 | E-GEOD-46632 | biostudies-arrayexpress
UnknownHistone demethylases and their roles in cancer epigenetics.
Not available
S-EPMC5279889 | biostudies-literature
TranscriptomicsKDM6 Inhibition induces DNA Damage Response (DDR) during ESC Differentiation but not during self-renewal.
The discovery of the first histone demethylase in 2004 (LSD1/KDM1) opened new avenues for the understanding of how histone methylation impacts cellular functions. A great number of histone demethylases have been identified since, which are potentially linked to gene regulation as well as to stem cel...
ORGANISM(S): Mus musculus 
2016-03-11 | E-GEOD-49886 | biostudies-arrayexpress
ProteomicsInvestigation of post-translational histone modifications in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumours affecting a range of body sites and have the highest degree of heritability of any cancer type. SDHA, SDHB, SDHC, SDHD and SDHAF2 (collectively SDHx) code for subunits of succinate dehydrogenase, an enzyme complex in the tricar...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD025689 | Pride
Histone post-translational modifications Paraganglioma Pheochromocytoma 
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