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TranscriptomicsGenome-wide analysis of the miR profile in human head and neck paraganglioma vs. Jacobson's (tympanic) nerve and SH-SY5Y neuroblastoma cells
The aim of the study was to assess whether changes in the expression of miRs could be implicated in the modulation of the NOTCH pathway in head and neck paragangliomas. Several miRs, notably including families (miR-34s, miR-200s) that target the NOTCH signaling pathway, resulted differentially expre...
ORGANISM(S): Homo sapiens 
2013-08-21 | E-GEOD-49190 | biostudies-arrayexpress
TranscriptomicsGene expression profile of a MDH2-mutated tumor
Transcriptional analysis of one primary paraganglioma One sample (primary paraganglioma) were hybridized onto a cDNA microarray in order to investigate differentially expressed genes
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-56573 | biostudies-arrayexpress
TranscriptomicsHigh-density genome-wide copy number variation (CNV) in human head and neck paragangliomas.
Gene-centric CNV analysis of 24 individual paraganglioma cases identified a list of 104 genes most significantly targeted by tumor-associated alterations. The NOTCH signaling pathway was the most significantly enriched term in the list. Overexpression of the relevant NOTCH pathway proteins in susten...
ORGANISM(S): Homo sapiens 
2013-08-21 | E-GEOD-49614 | biostudies-arrayexpress
ProteomicsDeep membrane proteome profiling of high-risk human paraganglioma
We combined glycopeptide enrichment by N-glyco-FASP (Zielinska et al., 2010), SPEG (Tian et al., 2007) with a hydrophobic segment-oriented hpTC method (Vít et al 2016) and a standard “detergent and trypsin” approach into a tree-pronged “Pitchfork” strategy for the analysis of membrane proteome in hi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD029344 | Pride
Lc-msms Paraganglioma Membrane proteome Human Pitchfork strategy 
TranscriptomicsDNA methylation analysis of phaeochromocytoma, paraganglioma and normal adrenal medulla samples
Illumina Infinium MethylationEPIC BeadChip array files from phaeochromocytoma, paraganglioma tumours of different genotypes and normal adrenal medulla control samples. This is the first study using high-resolution MethylationEPIC arrays and also includes a large number of Cluster 1 tumours (n=16) wh...
ORGANISM(S): Homo sapiens 
2023-12-21 | E-MTAB-13433 | biostudies-arrayexpress
TranscriptomicsSimilar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas
The similarity in gene-expression profiles suggest that PGL2, like SDHD, is involved in the functionality of the SDH complex, and that tumor formation in these three subgroups involves the same pathways as in SDH linked paragangliomas. We were not able to clarify the identity of PGL2 on 11q13. The l...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-12921 | biostudies-arrayexpress
GenomicsCopy number variation analysis of pheochromocytoma and paraganglioma
Cytogenetic analysis of 36 pheochromocytoma and four paraganglioma using high density arrays A series of 36 pheochromocytoma and four paraganglioma were analysed for genomic structural alterations using high density copy number arrays
ORGANISM(S): Homo sapiens 
2014-09-21 | E-GEOD-61594 | biostudies-arrayexpress
TranscriptomicsExpression profiles of pheochromocytoma and paraganglioma
Until now, it is nearly impossible to diagnose malignancy of peochormocytoma/paraganglioma with pathological examinations. The aim of the study is to find the genes which can be applied as a biomarker in the clinic to distinguish benign and malignant forms of pheochromocytoma/paraganglioma. We gener...
ORGANISM(S): Homo sapiens 
2014-08-17 | E-GEOD-60458 | biostudies-arrayexpress
TranscriptomicsCopy number profiles of pheochromocytoma and paraganglioma
Until now, it is nearly impossible to diagnose malignancy of pheochromocytoma/paraganglioma with pathological examinations. The aim of the study is to find the genes which can be applied as a biomarker in the clinic to distinguish benign and malignant forms of pheochromocytoma/paraganglioma. We gene...
ORGANISM(S): Homo sapiens 
2014-08-17 | E-GEOD-60457 | biostudies-arrayexpress
GenomicsGene expression profiling of paraganglioma (PGL)
Gene expression profiling of paraganglioma (PGL)
PRJNA508387 | ENA
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