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TranscriptomicsCardiopulmonary bypass (CPB) vs sham-operated controls
heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls
ORGANISM(S): Rattus norvegicus 
2010-05-27 | E-GEOD-924 | biostudies-arrayexpress
TranscriptomicsInvolvement of a chromatin remodeling complex in damage tolerance during DNA replication
ATP-dependent chromatin remodeling complexes have been shown to participate in DNA replication in addition to transcription and DNA repair. However, the mechanisms of their involvement in DNA replication remain unclear. Here, we reveal a specific function of the yeast INO80 chromatin remodeling comp...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-20 | E-GEOD-18570 | biostudies-arrayexpress
ProteomicsLinkage Reprogramming by Tailor-made E3s Reveals Polyubiquitin Chain Requirements in DNA Damage Bypass
A polyubiquitin chain can adopt a variety of shapes, depending on how the ubiquitin monomers are joined. However, the relevance of linkage for the signaling functions of polyubiquitin chains is often poorly understood because of our inability to control or manipulate this parameter in vivo. Here we ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-04-25 | PXD030735 | Pride
Ubiquitin E3 ligase Dna damage bypass Pcna 
TranscriptomicsRemote ischemic preconditioning in on-pump coronary artery bypass graft surgery
In this placebo-controlled randomized controlled trial, we tested whether remote ischemic preconditioning (RIPC) elicited by four 5-minute cycles of 300 mmHg of cuff inflation/deflation of the lower limb would reduce myocardial necrosis in isoflurane-anesthetized patients undergoing on-pump coronary...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-29396 | biostudies-arrayexpress
ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links part 2 of 2: AP-MS DATA (QUBIC)
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-13 | MSV000079577 | MassIVE
TranscriptomicsTranscription profiling of human atrial tissue from patients undergoing coronary artery bypass graft surgery to determine the effect of anesthesia on gene expression
Anesthetic gases elicit organ protection in patients undergoing coronary artery bypass graft (CABG) surgery. This study aimed at identifying myocardial transcriptional phenotypes and anesthetic-induced changes in gene expression to predict cardiovascular biomarkers and cardiac function after off-pu...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-4386 | biostudies-arrayexpress
TranscriptomicsDNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity
DNA replication is sensitive to damage in the template. To bypass lesions and complete replication, cells activate recombination-mediated (error-free) and translesion synthesis-mediated (error-prone) DNA damage tolerance pathways. Crucial for error-free DNA damage tolerance is template switching, wh...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-28 | E-GEOD-46260 | biostudies-arrayexpress
UnknownPost-replicative lesion processing limits DNA damage-induced mutagenesis.
Not available
S-EPMC11925729 | biostudies-literature
GenomicsBypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage [PRO-seq]
Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage [PRO-seq]
PRJNA1084906 | ENA
GenomicsBypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage [RNA-seq]
Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage [RNA-seq]
PRJNA1084905 | ENA
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